948350-91-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 149104-89-2 4-bromo-3-methylbenzylalcohol 
• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 148547-19-7 4-Bromo-3-methylbenzoic acid methyl ester 
• 78775-11-8 3-methyl-4-bromobenzaldehyde 

Downstream Products

• 948350-90-1 1-(4-bromo-3-methyl-benzyl)-5,7-diethyl-1H-[1,6]naphthyridin-2-one 
• 948351-04-0 4-(4-bromo-3-methyl-benzyl)-5-methyl-2-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 1563057-80-6 N-(4-bromo-3-methylbenzyl)-3,6,12,15-tetrathia-9-monoazaheptadecane 
• 1563057-77-1 4-bromo-3-methyliodomethylbenzene 
• 948351-06-2 4-(4-bromo-3-methyl-benzyl)-5-propyl-2-pyridin-2-yl-2,4-dihydro-[1,2,4]triazol-3-one 

Relevant academic research and scientific papers

Small molecule compound

The invention provides a small molecular compound, The small molecular compound is characterized by having a structure as shown in the following molecular general formula, wherein X1 and X2 are selected from carbon or nitrogen, G1 is a carbon ring or a heterocyclic ring with aromaticity, any one or more hydrogen atoms on the G1 ring are substituted by R1, wherein R1 is selected from nitrogen-containing groups. The small molecule compound can be used as an efficient and specific JAK kinase inhibitor, especially a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 dual inhibitor, or a Tyk2/JAK1 dual inhibitor or a Tyk2/Jak2 dual inhibitor.

FLUORESCENT PROBES FOR DETECTION OF COPPER

The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals.

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.