149143-25-9Relevant academic research and scientific papers
Metalation of Hantzsch Esters and Mixed Amide Esters: A General Route to C-2 Functionalized 1,4-Dihydropyridines
Poindexter, Graham S.,Licause, Joseph F.,Dolan, Peter L.,Foley, Michael A.,Combs, Charles M.
, p. 3811 - 3820 (1993)
1,4-Dihydropyridine (Hantzsch) diesters 3a-e readily undergo metalation at the C-2 methyl (vinylogous ester) position on treatment with alkyllithium bases.The resulting anion intermediates can be treated with electrophilic reagents to afford 1,4-dihydropy
