Metalation of Hantzsch Esters and Mixed Amide Esters: A General Route to C-2 Functionalized 1,4-Dihydropyridines

DOI: 10.1021/jo00067a012

Source and publish data:

Journal of Organic Chemistry p. 3811 - 3820 (1993)

Update date:2022-08-05

Topics:

Authors:

Poindexter, Graham S.

Licause, Joseph F.

Dolan, Peter L.

Foley, Michael A.

Combs, Charles M.

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Article abstract of DOI:10.1021/jo00067a012

1,4-Dihydropyridine (Hantzsch) diesters 3a-e readily undergo metalation at the C-2 methyl (vinylogous ester) position on treatment with alkyllithium bases.The resulting anion intermediates can be treated with electrophilic reagents to afford 1,4-dihydropy

Full text of DOI:10.1021/jo00067a012

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