131270-08-1

Basic information

• Product Name: D-β-Homophenylalanine, HPLC 98%
• Synonyms: β-homo-(S)-phenylalanine;β-homo-(S)-phenylalanin;(R)-b-Aminobenzenebutanoic acid;D-β-Homophenylalanine, HPLC 98%;(.BETA.R)-.BETA.-AMINO-BENZENEBUTANOIC ACID;(3R)-(-)-3-Amino-4-phenylbutyric acid;D-beta-Homophenylalanine;Benzenebutanoic acid, b-aMino-, (R)-
• CAS NO: 131270-08-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 131270-08-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 209-211 °C(Solv: water (7732-18-5); acetone (67-64-1))
• Boiling Point: 329.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.78±0.10(Predicted)
• CAS DataBase Reference: D-β-Homophenylalanine, HPLC 98%(CAS DataBase Reference)
• NIST Chemistry Reference: D-β-Homophenylalanine, HPLC 98%(131270-08-1)
• EPA Substance Registry System: D-β-Homophenylalanine, HPLC 98%(131270-08-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 131270-08-1(Hazardous Substances Data)

Usage

General Description

D-β-Homophenylalanine, HPLC 98% is a chemical compound with a purity of 98% when analyzed by high performance liquid chromatography (HPLC). It is an enantiomer of the natural amino acid phenylalanine, and it is commonly used in the synthesis of pharmaceuticals and other organic compounds. This chemical has a variety of potential applications in the field of medicinal chemistry and drug development due to its ability to mimic the structure and function of phenylalanine in biological systems. Its high purity makes it suitable for use in research and development, as well as in the production of pharmaceutical products.

Upstream product

• 5130-24-5 Vinyl chloroformate 
• 153708-38-4 (S,S)-6-benzyl-2-tert-butyl-1,3-dimethyl-4-pyrimidinone 
• 149193-77-1 3-amino-4-phenyl-butyric acid ethyl ester 
• 131270-13-8 (R)-3-N,N-dibenzylamino-4-phenylbutanenitrile 
• 178897-35-3 (4S,5R)-4-methoxycarbonylmethyl-5-phenyloxazolidin-2-one 
• 777885-07-1 (+/-)-4-benzyl-2-azetidinone 
• 131270-16-1 (R)-3-N,N-dibenzylamino-4-phenylbutanoic acid 
• 193954-28-8 (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid 
• 51871-62-6 (S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid 
• 211618-76-7 (S)-4-benzyl-2-azetidinone 
• 1039025-18-7 N-[(1S)-1-cyanomethyl-2-phenylethyl]-2,4,6-trimethylbenzenesulfonamide 
• 97206-05-8 methyl N-(benzyloxycarbonyl)-(3S)-3-amino-4-phenylbutanoate 
• 153708-33-9 (S)-6-benzyl-2-tert-butyl-1-methoxymethyl-3-methyl-2,3-dihydro-4(1H)-pyrimidinone 
• 100-52-7 benzaldehyde 

Downstream Products

• 26250-86-2 (S)-3-benzyloxycarbonylamino-4-phenylbutyric acid 
• 145149-49-1 (R)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate 
• 200949-32-2 N-[(2R)-1-carbamoyl-3-phenylpropan-2-yl]carbamic acid tert-butyl ester 
• 101555-61-7 (R)-3-t-butoxycarbonylamino-4-phenylbutyric acid 
• 120378-17-8 threo-(2RS)-3-t-butoxycarbonylamino-4-phenylbutanoic acid 
• 211619-01-1 (2S,3R)-2-Benzyl-3-methyl-4-oxo-azetidine-1-carboxylic acid (pyridin-4-ylmethyl)-amide 
• 211619-02-2 (2S,3S)-2-Benzyl-3-methyl-4-oxo-azetidine-1-carboxylic acid (pyridin-4-ylmethyl)-amide 
• 211618-81-4 (3R,4S)-4-Benzyl-1-(tert-butyl-dimethyl-silanyl)-3-methyl-azetidin-2-one 
• 211618-79-0 (3S,4S)-4-Benzyl-1-(tert-butyl-dimethyl-silanyl)-3-methyl-azetidin-2-one 

Relevant articles and documents

Candida antarctica lipase B-catalyzed ring opening of 4-arylalkyl-substituted β-lactams

The Lipolase-catalyzed ring opening of racemic 4-benzyl- 3 and 4-phenylethyl-2-azetidinone 4 was performed with 0.5 equiv of H2O in diisopropyl ether at 45 °C. The resulting (S)-β-amino acid 5 or 6 (ee ≥ 87%) and (R)-β-lactam 7 or 8 (ee >99%) enantiomers could easily be separated. The ring opening of enantiomeric β-lactams with 18% aqueous HCl afforded the corresponding enantiopure β-amino acid hydrochlorides 9 and 10 (ee >99%).

Thermal cleavage of the Fmoc protection group

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.

HETEROCYCLIC MODULATORS OF PKB

The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.