14924-72-2

Upstream product

• 64-18-6 formic acid 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 17377-95-6 benzyl(4-methoxyphenyl)amine 
• 124-38-9 carbon dioxide 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 17377-95-6 benzyl(4-methoxyphenyl)amine 

Relevant academic research and scientific papers

Reductive Coupling of CO2, Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides

We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO2, primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss.

Thermal and microwave-assisted N-formylation using solid-supported reagents

A rapid and easy route to formamides by microwave assisted N-formylation of primary and secondary amines is described. Using an insoluble polymer or an inorganic solid-supported reagent as a formylating agent, microwave irradiation furnished the corresponding formamides in high yields, with reduced reaction time and solvent volume over the conventional approach.

Process for the preparation of fluoran compounds which are substituted by basic groups

A process for the preparation of fluoran compounds which are substituted by basic groups and have the formula STR1 wherein R1, R2 and R3 are each independently hydrogen, halogen or lower alkyl, or R1 and R2 together with the carbon atom to which they are attached are a fused benzene nucleus, X1 and X2 are each independently hydrogen, unsubstituted or substituted alkyl, cycloalkyl, aryl or aralkyl, or X1 and X2 together with the nitrogen atom to which they are attached are a 5- or 6-membered heterocyclic radical, and Y is unsubstituted or substituted alkyl, cycloalkyl, aryl or aralkyl, and the ring A is unsubstituted or substituted, which process comprises reacting a ketonic acid of the formula STR2 with a substituted 4-formylaminophenol derivative of the formula STR3 wherein A, R1, R2, R3, X1, X2 and Y have the meanings assigned to them and Z is hydrogen, lower alkyl, formyl or lower alkanoyl, deformylating the resultant phthalide of the formula STR4 and cyclising the deformylated compound by intramolecular condensation to give the fluoran of the formula (1).