149244-21-3

Upstream product

• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 107-05-1 3-chloroprop-1-ene 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 1730-25-2 allylmagnesium bromide 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 

Downstream Products

• 328570-78-1 4-(2-bromo-5-methoxy-phenyl)-butan-1-ol 
• 1444-59-3 6-(m-methoxyphenyl)hex-1-en-3-one 
• 104174-43-8 4-(3-methoxyphenyl)butan-1-ol 
• 126210-14-8 Astrogorgadiol 
• 281224-85-9 4-(5-methoxy-2-methyl-phenyl)-butyraldehyde 
• 328570-79-2 4-methyl-3-(4-hydroxybutyl)anisole 
• 328570-81-6 6-(5-methoxy-2-methyl-phenyl)-1-phenoxy-hexan-3-one 
• 328570-85-0 (1R,7aR)-1-((R)-1,5-Dimethyl-hex-4-enyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one 
• 328570-89-4 (1R,3aS,4S,7aR)-1-((R)-1,5-Dimethyl-hex-4-enyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-inden-5-one 
• 328570-91-8 (1R,3aS,4S,5R,7aR)-4-(5-methoxy-2-methylphenethyl)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydro-1H-inden-5-ol 
• 328570-87-2 (1R,3aS,4S,7aR)-1-((R)-1,5-Dimethyl-hexyl)-4-[2-(5-methoxy-2-methyl-phenyl)-ethyl]-7a-methyl-octahydro-inden-5-one 
• 27752-24-5 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 1443497-75-3 C₁₂H₁₄O₂ 
• 1189354-07-1 4-bromo-3-n-butylanisole 

Relevant academic research and scientific papers

Stereoselective Convergent Synthesis of Tetrahydro-5 H-benzo[c]fluorene via Nine-Membered Ring-Closing Metathesis and Transannular Acid-Mediated Cyclization/Nucleophilic Addition

The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3-en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closi

Transition-Metal-Free ipso-Trifluoromethylthiolation of Lithium Aryl Boronates

A transition-metal-free direct trifluoromethylthiolation of the ipso-carbon of lithium aryl boronates with trifluoromethanesulfenate under mild conditions was described. In addition, late-stage site-selective C-H borylation/trifluoromethylation and C-Cl b

Iridium-catalyzed borylation of secondary benzylic C-H bonds directed by a hydrosilane

Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1, 10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.

Synthesis of five- and six-membered benzocyclic ketones through intramolecular alkene hydroacylation catalyzed by Nickel(0)/N-Heterocyclic Carbenes

Getting some closure: Mechanistic studies supported the participation of an oxanickelacycle complex in the hydroacylation step of the title reaction, which proceeds without decarbonylation even in the absence of well-known chelation assistance by heteroatoms. Copyright

Synthesis of (-)-astrogorgiadiol

Reaction of Rh2(S)-PTPA4 with the (R)-citronellol-derived α-diazo-β-ketoester 1 led to the formation of cyclic β-ketoester 2 in 95% yield and 48% diastereomeric excess. The purity of 2 was increased to >99% de after one crystallization. To demonstrate its utility in steroid total synthesis, the β-ketoester 2 was carried on to secosteroid (-)-astrogorgiadiol (3), a naturally occuring vitamin D analogue with antiproliferative properties.