149312-08-3Relevant academic research and scientific papers
Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
Renders, Marleen,Dumbre, Shrinivas,Abramov, Mikhail,Kestemont, Donaat,Margamuljana, Lia,Largy, Eric,Cozens, Christopher,Vandenameele, Julie,Pinheiro, Vitor B.,Toye, Dominique,Frère, Jean-Marie,Herdewijn, Piet
, p. 2160 - 2168 (2019)
Six 1,5-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucleotide analogues into a DNA duplex overhang using recently evolved XNA polymerases is compared. Long, mixed HNA sequences featuring the base modifications are generated. The apparent binding affinity of four of the nucleotides to the enzyme, the rate of the chemical step and of product release, plus the specificity constant for the incorporation of these modified nucleotides into a DNA duplex overhang using the HNA polymerase T6G12 I521L are determined via pre-steady-state kinetics. HNA polymers displaying aromatic functional groups could have significant impact on the isolation of stable and high-affinity binders and catalysts, or on the design of nanomaterials.
5-substituted pyrimidines with a 1,5-anhydro-2,3-dideoxy-D-arabino- hexitol moiety at N-1: Synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase
Ostrowski, Tomasz,Wroblowski, Berthold,Busson, Roger,Rozenski, Jozef,De Clercq, Erik,Bennett, Matthew S.,Champness, John N.,Summers, William C.,Sanderson, Mark R.,Herdewijn, Piet
, p. 4343 - 4353 (1998)
A new series of anhydrohexitol nucleosides are described. These compounds have a pyrimidine base moiety substituted in the 5-position with a chloro (1b), trifluoromethyl (1c), vinyl (1d), 2-thienyl (1e), ethynyl (1f) or propynyl (1g) substituent. The viny
Radiosynthesis and in vitro evaluation of 1-(tetrahydro-5-hydroxy-6- (hydroxymethyl)-2H-pyran-3-yl)-5-[125I]iodouracil: A new potential agent for HSV1-tk reporter gene monitoring
Jo, Nam Hyun,Kim, Jung Young,El-Gamal, Mohammed I.,Choi, Won-Kyoung,Park, Jin-Hun,Kim, Eun Jung,Cho, Jung-Hyuck,Ha, Hyun-Joon,Choi, Tae Hyun,Oh, Chang-Hyun
, p. 93 - 97 (2011)
Synthesis, radiolabelling, and in vitro evaluation of a new 125I-labelled iodouracil hexitol nucleoside analogue are reported. The target compound was successfully synthesized by an iodination-destannylation method and then purified by reverse
