149471-91-0

Basic information

• Product Name: 1H-Benzimidazol-6-ol(9CI)
• Synonyms: 1H-Benzimidazol-6-ol(9CI);1H-benzo[d]iMidazol-5-ol
• CAS NO: 149471-91-0
• Molecular Formula: C7H6N2O
• Molecular Weight: 0
• Product Categories: BENZIMIDAZOLE
• Mol File: 149471-91-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 469.1°C at 760 mmHg
• Flash Point: 237.5°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 2.01E-09mmHg at 25°C
• Refractive Index: 1.76
• CAS DataBase Reference: 1H-Benzimidazol-6-ol(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-6-ol(9CI)(149471-91-0)
• EPA Substance Registry System: 1H-Benzimidazol-6-ol(9CI)(149471-91-0)

Safety Data

• Hazardous Substances Data: 149471-91-0(Hazardous Substances Data)

Usage

Uses

1H-Benzo[D]Imidazol-5-ol is a pathway intermediate in the anaerobic biosynthesis of the lower ligand of vitamin B12 (cobalamin).

InChI:InChI=1/C7H6N2O/c10-5-1-2-6-7(3-5)9-4-8-6/h1-4,10H,(H,8,9)

Upstream product

• 4887-80-3 5-methoxy-1H-benzimidazole 
• 50591-21-4 5-ethoxybenzimidazole 
• 64-18-6 formic acid 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 106658-14-4 4-methoxy-1,2-phenylenediamine hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 25635-88-5 5-amino-1-(β-D-ribofuranosyl)imidazole 5'-phosphate 

Downstream Products

• 816463-40-8 tert-butyl N-[1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-yl]carbamate 
• 128728-05-2 4-(5-Hydroxy-1H-benzoimidazol-4-ylazo)-benzenesulfonic acid 
• 128728-03-0 4-Phenylazo-1H-benzoimidazol-5-ol 
• 128728-04-1 4-(4-Nitro-phenylazo)-1H-benzoimidazol-5-ol 

Relevant articles and documents

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Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method

The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists

A series of novel benzimidazoles are discussed as NR2B-selective N-methyl-d-aspartate (NMDA) receptor antagonists. High throughput screening (HTS) efforts identified a number of potent and selective NR2B antagonists such as 1. Exploration of the substituents around the core of this template identified a number of compounds with high potency for NR2B (pIC50 >7) and good selectivity against the NR2A subunit (pIC50 2+ and radioligand binding studies. These agents offer potential for the development of therapeutics for a range of nervous system disorders including chronic pain, neurodegeneration, migraine and major depression.

Mild and general one-pot reduction and cyclization of aromatic and heteroaromatic 2-nitroamines to bicyclic 2 H -imidazoles

A one-pot procedure for the conversion of aromatic and heteroaromatic 2-nitroamines into bicyclic 2H-benzimidazoles is described. The procedure employs formic acid, iron powder, and an additive such as NH4Cl to reduce the nitro group and effect the imidazole cyclization with high-yielding conversions generally within one to two hours. The compatibility with a wide range of functionality demonstrates the general utility of this procedure.