4887-80-3

Basic information

• Product Name: 5-METHOXYBENZIMIDAZOLE
• Synonyms: 5-Methoxy-1H-benzoiMidazole;5-Methoxy-1H-benzo[d]iMidazole;5-Methoxybenzimidazole 97%;BUTTPARK 146\15-76;5-METHOXYBENZIMIDAZOLE;5-METHOXY-1H-BENZIMIDAZOLE;5-Methoxybenzimidazole,99%;1H-Benzimidazole,5-methoxy-(9CI)
• CAS NO: 4887-80-3
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• EINECS: 225-502-9
• Product Categories: BENZIMIDAZOLE;pharmacetical;Imidazol&Benzimidazole;Benzimidazoles;Building Blocks;Heterocyclic Building Blocks
• Mol File: 4887-80-3.mol
• Article Data: 46

Chemical Properties

• Melting Point: 121-126 °C(lit.)
• Boiling Point: 390.2 ºC at 760 mmHg
• Flash Point: 141.7 ºC
• Appearance: White to brown powder
• Density: 1.244 g/cm³
• Vapor Pressure: 6.07E-06mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.12±0.10(Predicted)
• CAS DataBase Reference: 5-METHOXYBENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYBENZIMIDAZOLE(4887-80-3)
• EPA Substance Registry System: 5-METHOXYBENZIMIDAZOLE(4887-80-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• Hazardous Substances Data: 4887-80-3(Hazardous Substances Data)

Usage

Chemical Properties

White to brown powder

Uses

6-Methoxy-1H-benzimidazole has been studied for its anti-proliferative activity, and a preliminary in vivo toxicity study against a panel of non-small cell lung cancer cell lines.

InChI:InChI=1/C8H8N2O/c1-11-6-2-3-7-8(4-6)10-5-9-7/h2-5H,1H3,(H,9,10)

Upstream product

• 64-18-6 formic acid 
• 96-96-8 4-methoxy-2-nitroaniline 
• 67-56-1 methanol 
• 37052-78-1 6-methoxy-1H-benzoimidazole-2-thiol 
• 64-17-5 ethanol 
• 100-51-6 benzyl alcohol 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 37052-78-1 2-Mercapto-5-methoxybenzimidazole 
• 4252-31-7 N-formylbenzamide 
• 124-38-9 carbon dioxide 
• 67-68-5 dimethyl sulfoxide 
• 119072-55-8 tert-butylisonitrile 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1135119-72-0 C₂₂H₁₇F₃N₂O₄S 
• 1135119-69-5 C₂₂H₁₇F₃N₂O₄S 
• 10394-42-0 6-methoxy-1-methylbenzimidazole 
• 1008361-66-7 4-Bromo-5-(methyloxy)-1H-benzimidazole 
• 1008361-65-6 5-bromo-6-methoxy-1H-benzo[d]imidazole 
• 22019-71-2 N¹-benzyl-5-methoxybenzimidazole 

Relevant articles and documents

Novel approach to the synthesis of omeprazole: An antipeptic ulcer agent

A novel approach for the synthesis of omeprazole, a potent antiulcer drug, is described. The synthetic procedure involved the formation of an ester of the 5-methoxy thiobenzimidazole followed by coupling of the ester with the Grignard reagent of 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine. Copyright Taylor & Francis Group, LLC.

Highly Efficient and Catalyst-Free Synthesis of Benzimidazoles in Aqueous Media

Abstract: A convenient and highly efficient, catalysts-free synthesis of benzimidazoles in an aqueous medium has been developed. The conditions of the synthesis were optimized, and its scope was successfully extended to various substrates with good to excellent yields. The experimental procedure is simple, and the products can be isolated by filtration followed by recrystallization from water.

Method for synthesizing benzimidazole from carbon dioxide and o-phenylenediamine compound

The invention discloses a method for synthesizing benzimidazole from carbon dioxide and an o-phenylenediamine compound, the method is characterized in that an amino-containing functionalized ordered mesoporous polymer is used as a catalyst, o-phenylenediamine and carbon dioxide are used as raw materials, dimethylaminoborane is used as a hydrogen reduction reagent, carbon dioxide and the o-phenylenediamine compound are catalyzed to react in an NMP solvent to generate a benzimidazole compound, wherein the dosage of a catalyst is 0.01-1mol% based on the nitrogen content of the o-phenylenediamine compound; the filling pressure of the carbon dioxide is 0.1-2MPa; the reaction temperature is 60-180DEG C; the molar ratio of the catalyst to the NMP is 1:50-100. Compared with the prior art, the catalyst has the advantages of simple preparation, high catalytic activity, capability of catalyzing the reaction of carbon dioxide and the o-phenylenediamine compound under mild conditions to generate benzimidazole and derivatives thereof, and the like.