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149496-40-2

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149496-40-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 149496-40-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,4,9 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 149496-40:
(8*1)+(7*4)+(6*9)+(5*4)+(4*9)+(3*6)+(2*4)+(1*0)=172
172 % 10 = 2
So 149496-40-2 is a valid CAS Registry Number.

149496-40-2Downstream Products

149496-40-2Relevant articles and documents

Stability of aztreonam in AZACTAM

Zajac, Marianna,Jelinska, Anna,Cielecka-Piontek, Judyta,Oszczapowicz, Irena

, p. 599 - 603 (2005)

The influence of temperature and relative humidity on the stability of aztreonam in AZACTAM was investigated. Changes of the concentration of aztreonam were followed using the HPLC method with UV detection. The first-order rate constants of the reversible reaction of isomerization Z-aztreonam ? E-aztreonam and the parallel reaction Z-aztreonam → products were determined at RH = 76.4% and T = 313, 323, 333, 343 and 353 K, and at T = 343 K and RH = 50.9%, 60.5%, 66.5% and 76.4%. The thermodynamic parameters-energy, enthalpy and entropy of these reactions were calculated.

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2

Ding, Pingyu,Duncton, Matthew A. J.,Fan, Dazhong,Gordon, Eric M.,Grygorash, Ruslan,Li, Xianfeng,Low, Eddy,Ni, Zhi-Jie,Qi, Longwu,Sun, Jiawei,Wang, Brian J.,Yu, Guijun

, p. 162 - 165 (2020/01/31)

Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.

AN IMPROVED PROCESS FOR THE PREPARATION OF MONOBACTAM ANTIBIOTIC

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Page/Page column 8-9, (2008/06/13)

The present invention relates to the process for the preparation of monobactam antibiotic of formula (I). More particularly, the present invention relates to the preparation of Aztreonam of formula (I) from its precursor, tertiary butyl ester of Aztreonam of formula (II).

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