149554-44-9Relevant academic research and scientific papers
Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant
Liao, Lian-Yan,Liu, Kun-Ming,Duan, Xin-Fang
, p. 9856 - 9867 (2015/11/03)
The first cobalt-catalyzed oxidative cross-coupling reaction of two aryl metal reagents is described. An equivalent amount of two aryl Grignard or lithium reagents, after mediation by an equivalent amount of simple ClTi(OEt)3, was facilely assembled under the catalysis of 1 mol % of CoCl2/10 mol % of DMPU using oxygen. The cross-couplings between various aryl metal reagents, especially between two structurally similar aryl Grignard reagents, proceeded smoothly and selectively and, thus, provided a highly general and efficient method for the construction of biaryl compounds.
Synthesis of Substituted Fluorenones and Substituted 3',3'-Dichlorospiro and Their Reactivities
Chew, Warren,Hynes, Rosemary C.,Harpp, David N.
, p. 4398 - 4404 (2007/10/02)
Several novel 9-fluorenones were synthesized and were used as precursors in an attempt to prepare unique substituted 3',3'-dichlorospiro.Several of the thiiranes were unstable and desulfurized during their preparation (7a-d, 11, 12). 3',3'-Dichloro(2,5-dimethoxyspiro (7f) was prepared along with 2,2-dichloro-3,3-bis(4-methoxyphenyl)thiirane (16), and 3',3'-dichloro-10,11-dihydrospirocycloheptane-5,2'-thiirane> (17) all of which were stable at room temperature.A study of the reactivity of fluorenyl-substituted thiiranes and other related thiiranes showed that the extent of aromaticity of the substituents at the 3-position of the thiiranes influences their stabilities.
