149577-05-9Relevant articles and documents
Pyrimido-pyridone compound and application thereof
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Paragraph 0326; 0328; 0330, (2021/05/08)
The invention provides a pyrimido-pyridone compound with a structure as shown in a formula I, pharmaceutically acceptable salts, stereoisomers, tautomers, N-oxides or prodrug molecules of the pyrimido-pyridone compound and applications thereof. The compound can be used as a protein kinase inhibitor, can effectively inhibit the activity of TTK protein kinase and can inhibit proliferation, migration and invasion of various tumor cells.
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones
Hossain, Mohammad,Das, Umashankar,Umemura, Naoki,Sakagami, Hiroshi,Balzarini, Jan,De Clercq, Erik,Kawase, Masami,Dimmock, Jonathan R.
, p. 2206 - 2214 (2016/04/26)
A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cytotoxic agents. These compounds displayed potent cytotoxic properties towards human Molt4/C8, CEM, HSC-2, HSC-3 and HSC-4 neoplasms and also to murine L1210