14959-73-0

Upstream product

• 2447-93-0 N-(o-chlorobenzoyl)-p-toluidine 
• 501-65-5 diphenyl acetylene 
• 62303-05-3 2-iodo-N-(p-tolyl)benzamide 
• 136926-09-5 2-bromo-N-(4-methylphenyl)benzamide 
• 106-49-0 p-toluidine 
• 609-67-6 2-Iodobenzoyl chloride 
• 582-78-5 N-(4-methylphenyl)benzamide 

Relevant academic research and scientific papers

Isoquinolinium salts from o-halobenzaldehydes, amines, and alkynes catalyzed by nickel complexes: Synthesis and applications

Aza-nickelacycles: An atom-economic nickel-catalyzed synthesis of isoquinolinium salts is reported. The salts are readily reduced to the corresponding reductive homo-coupling products and oxidized to isoquinolinones (see scheme). Isoquinolinones are impor

Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing various functional groups are obtained in moderate to excellent yields.

Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C[sbnd]H/N[sbnd]H activation

Pd/C-catalyzed direct synthesis of N-aryl and N-alkyl isoquinolones was developed via the annulation reactions of benzamides and alkynes in high yields (up to 99%) through the cleavage of C[sbnd]H/N[sbnd]H bonds. The reaction was ligand-free and air was used as oxidant. High regioselectivities were found when unsymmetrical alkynes or meta-benzamides were used as substrates. The heterocyclic carboxamide substrates, such as furan and thiophene derivatives, also afforded the corresponding products in high yields.

Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes

2-Iodobenzamides reacted with alkynes in the presence of a nickel(0)/P(4-ClC6H4)3 catalyst to produce substituted (1H)-isochromen-1-imines. The reaction proceeded through the formation of an oxanickelacycle, alkyne insertion, and reductive elimination.

Synthesis of highly substituted isoquinolone derivatives by nickel-catalyzed annulation of 2-halobenzamides with alkynes

(Equation Presented). An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the total synthes

Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: Synthesis of polycyclic amides

A methodology for the high yield and facile synthesis of isoquinolones from benzamides and alkynes via the oxidative ortho C-H activation of benzamides has been developed. Ag2CO3 proved to be an optimal oxidant when MeCN was used as