14959-73-0Relevant articles and documents
Isoquinolinium salts from o-halobenzaldehydes, amines, and alkynes catalyzed by nickel complexes: Synthesis and applications
Korivi, Rajendra Prasad,Wu, Yu-Chen,Cheng, Chien-Hong
, p. 10727 - 10731 (2009)
Aza-nickelacycles: An atom-economic nickel-catalyzed synthesis of isoquinolinium salts is reported. The salts are readily reduced to the corresponding reductive homo-coupling products and oxidized to isoquinolinones (see scheme). Isoquinolinones are impor
Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C[sbnd]H/N[sbnd]H activation
Shu, Zhen,Guo, Yuntao,Li, Wei,Wang, Baiquan
, p. 292 - 297 (2017/09/30)
Pd/C-catalyzed direct synthesis of N-aryl and N-alkyl isoquinolones was developed via the annulation reactions of benzamides and alkynes in high yields (up to 99%) through the cleavage of C[sbnd]H/N[sbnd]H bonds. The reaction was ligand-free and air was used as oxidant. High regioselectivities were found when unsymmetrical alkynes or meta-benzamides were used as substrates. The heterocyclic carboxamide substrates, such as furan and thiophene derivatives, also afforded the corresponding products in high yields.
Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: Synthesis of polycyclic amides
Song, Guoyong,Chen, Dan,Pan, Cheng-Ling,Crabtree, Robert H.,Li, Xingwei
supporting information; experimental part, p. 7487 - 7490 (2011/02/21)
A methodology for the high yield and facile synthesis of isoquinolones from benzamides and alkynes via the oxidative ortho C-H activation of benzamides has been developed. Ag2CO3 proved to be an optimal oxidant when MeCN was used as
