14963-34-9

Basic information

• Product Name: 4-Amino-4'-hydroxybenzophenone
• Synonyms: 4-Amino-4'-hydroxybenzophenone;(4-aminophenyl)-(4-hydroxyphenyl)methanone
• CAS NO: 14963-34-9
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23
• Mol File: 14963-34-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 184°C
• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Amino-4'-hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-4'-hydroxybenzophenone(14963-34-9)
• EPA Substance Registry System: 4-Amino-4'-hydroxybenzophenone(14963-34-9)

Safety Data

• Hazardous Substances Data: 14963-34-9(Hazardous Substances Data)

Usage

Preparation

Obtained by heating 4-hydroxy-4?-nitrodiphenylmethane (SM), sulfur and sodium hydroxide in 50% ethanol in a boiling water bath for 7 h (60%). In this reaction, oxidation of the methylene group to a carbonyl group occurred together with reduction of the nitro group. The oxidizing agent for the methylene group was the tetrasulfide. SM was obtained by diazotization of 4-amino-4?-nitrodiphenylmethane (83%).

Upstream product

• 1151-94-6 4-methoxy-4'-nitrobenzophenone 
• 100-66-3 methoxybenzene 
• 122-04-3 4-nitro-benzoyl chloride 
• 18920-70-2 4-hydroxy-4'-nitrobenzophenone 

Downstream Products

• 1108159-48-3 C₃₁H₂₄NO₄P 
• 1190991-50-4 C₃₁H₂₅N₂O₃P 
• 264603-54-5 4,5-dihydro-N-[4-(4-methoxybenzoyl)phenyl]-3-(3-pyridinyl)-5-isoxazolecarboxamide 
• 31684-69-2 [4-(2-Ethoxy-ethylamino)-phenyl]-(4-hydroxy-phenyl)-methanone 

Relevant articles and documents

Inducing apoptosis through upregulation of p53: structure–activity exploration of anthraquinone analogs

We previously reported a series of p53-elevating anthraquinone compounds with considerable cytotoxicity for acute lymphoblastic leukemia (ALL) cells. To further develop this class of compounds, we examined the effect of a few key structural features on the anticancer structure–activity relationship (SAR) in ALL cells. The active analogs showed comparable cytotoxicity and upregulation of p53 but did not induce significant downregulation of MDM2 as seen with the lead compound AQ-101, indicating the importance of the anthraquinone core scaffold for MDM2 regulation. The result from the current study not only contributes to the SAR framework of these anthraquinone derivatives but also opens up new chemical space for further optimization work.