1256490-52-4

Basic information

• Product Name: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
• Synonyms: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester;Isopropyl (2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate;propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate;N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
• CAS NO: 1256490-52-4
• Molecular Formula: C₁₈H₁₇F₅NO₅P
• Molecular Weight: 453.297057
• Mol File: 1256490-52-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 442.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.405±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.81±0.70(Predicted)
• CAS DataBase Reference: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(1256490-52-4)
• EPA Substance Registry System: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(1256490-52-4)

Safety Data

• Hazardous Substances Data: 1256490-52-4(Hazardous Substances Data)

Usage

General Description

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester is a chemical compound that is a derivative of the amino acid alanine. It is also known as F-PhAla-OH and is commonly used in peptide synthesis and pharmaceutical research. L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester is an ester of alanine and a phosphinate, and its pentafluorophenoxy substituent makes it a potent inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), which is involved in the regulation of blood glucose levels. F-PhAla-OH may have potential applications in the development of new drugs for the treatment of diabetes and other metabolic disorders. Additionally, it may be used as a research tool in the study of DPP-4 and related enzymes.

Upstream product

• 338-69-2 D-Alanine 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 770-12-7 O-phenyl phosphorodichloridate 
• 67-63-0 isopropyl alcohol 
• 39825-33-7 isopropyl L-alanine 
• 261909-49-3 phenyl(isopropoxy-L-alaninyl) phosphorochloridate 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 17788-07-7 2,3,4,5,6-pentafluorophenyl dichlorophosphate 
• 108-95-2 phenol 
• 2263-53-8 sodium pentafluorophenolate 

Downstream Products

• 1403574-71-9 C₂₂H₃₀N₇O₈P 
• 1605283-78-0 C₃₁H₄₄N₅O₉P 
• 1605283-80-4 C₃₁H₄₄N₅O₉P 
• 1605283-84-8 C₃₁H₄₂N₅O₁₀P 
• 1605283-86-0 C₂₆H₃₆N₇O₉P 
• 1605283-89-3 C₃₀H₄₂N₇O₁₀P 
• 1605283-90-6 C₂₆H₃₆N₇O₉P 
• 1605283-94-0 C₂₇H₃₅N₄O₁₀P 
• 1567899-65-3 C₂₃H₂₈N₃O₁₀P 
• 1610022-14-4 C₂₇H₃₄N₃O₁₁P 
• 1231747-08-2 (S)-2-{(S)-[(1R,4R,5R)-5-(2-amino-6-methoxy-purin-9-yl)-4-(R)-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-ylmethoxy]phenoxy-phosphorylamino}propionic acid isopropyl ester 
• 1334513-02-8 (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester 
• 1337529-56-2 (S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 

Relevant articles and documents

Nucleotide derivative and pharmaceutical composition and application thereof

The invention discloses a nucleotide derivative and a pharmaceutical composition and application thereof, wherein the nucleotide derivative is as shown in a formula (I). The compound can be used for preparing anti-virus infection drugs.

CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF

An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

Preparation method for phosphamide compound used for synthesis chiral drug

The invention provides a preparation method for a phosphamide compound used for synthesis of a chiral drug. According to the invention, a compound II with high yield and high purity can be prepared byadopting a NaHCO3 aqueous solution with a specific pH value and a specific volume-to-mass ratio as a solvent for pulping and controlling a temperature and a stirring speed during pulping. By adoptionof a reaction system provided by the invention, an organic solvent is not needed; the discharge of a large amount of an organic solvent waste liquid is reduced; and the process is environmentally-friendly, green and pollution-free.