149789-77-5

Basic information

• Product Name: methyl (4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetate
• Synonyms: 3-thiazolidineacetic acid, 4-oxo-2-thioxo-, methyl ester
• CAS NO: 149789-77-5
• Molecular Formula: C₆H₇NO₃S₂
• Molecular Weight: 205.2547
• Mol File: 149789-77-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 302.1°C at 760 mmHg
• Flash Point: 136.5°C
• Density: 1.5g/cm³
• Vapor Pressure: 0.00101mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: methyl (4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetate(149789-77-5)
• EPA Substance Registry System: methyl (4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetate(149789-77-5)

Safety Data

• Hazardous Substances Data: 149789-77-5(Hazardous Substances Data)

Upstream product

• 21055-37-8 methyl isothiocyanatoacetate 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 5718-83-2 rhodanine 3-acetic acid 
• 100-52-7 benzaldehyde 

Relevant articles and documents

PROCESS FOR PREPARING RHODANINE-3-ACETIC ACID: A KEY INTERMEDIATED OF EPALRESTAT

A process for preparation of (4-oxo-2-thioxo-1,3-thiazolidin-3-yl) acetic acid comprising: (a) reaction of compound of formula (VIII) wherein Y is Cl, Br, I, OTs, OMs and R is C1-8 alkyl, benzyl, cycloalkyl, phenyl, substituted phenyl and their like; with a compound of formula (VIIIA) wherein M is K, Na or Li, preferably K; R1 is C1-4 alkyl, benzyl, C1-C8 cycloalkyl, phenyl and their like, in aqueous medium to give a compound of formula (IX) (b) cyclizing a compound of formula (IX) using a base to give a compound of formula (X) in a solvent. (c) hydrolyzing (X) using aqueous mineral acid.