149885-10-9

Upstream product

• 145071-98-3 (2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoic acid 
• 188911-98-0 1-(trimethylsilyl)-3(R*,S*)-methoxy-4(S)-(benzyloxy)-1-pentyne 
• 149836-92-0 (S)-3-[(2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-5-trimethylsilanyl-pent-4-ynoyl]-4-isopropyl-oxazolidin-2-one 
• 149836-93-1 3-[(2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-5-trimethylsilanyl-pent-4-ynoyl]-oxazolidin-2-one 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 175656-30-1 (2S,3S)-2-((R)-1-Amino-ethyl)-3-benzyloxy-butyric acid 
• 149885-12-1 (2S,3R)-2-((S)-1-Benzyloxy-ethyl)-3-tert-butoxycarbonylamino-butyric acid 

Relevant academic research and scientific papers

Formal total syntheses of the β-lactam antibiotics thienamycin and PS-5

Chiral nonracemic acetylenic acids of general structure 11, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 12 by a two-step sequence involving Curtius rearrangement followed by o

A versatile synthesis of β-amino acids using the Nicholas reaction. I. Application to β-lactams of the carbapenem class

Homochiral acetylenic acids of general structure 10, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 11 by a two step sequence involving Curtius rearrangement followed by oxidativ