14990-93-3

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 104-94-9 4-methoxy-aniline 
• 144223-29-0 1H-1,2,3-benzotriazol-1-yl(2-pyridinyl)methanone 
• 109-04-6 2-bromo-pyridine 
• 13939-06-5 molybdenum hexacarbonyl 
• 98-98-6 2-Picolinic acid 
• 4334-27-4 4‐methoxy‐N‐(pyridin‐2‐ylmethyl)aniline 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 67-56-1 methanol 
• 10354-53-7 N-phenylpicolinamide 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 2524-52-9 ethyl-2-picolinate 

Downstream Products

• 76540-11-9 N-(4-Methoxy-phenyl)-pyridine-2-carboximidoyl chloride; hydrochloride 
• 183436-46-6 5-Hydroxy-6-(4-methoxy-phenyl)-5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one 
• 1075281-30-9 [IrH₂(PPh₃)2(N-(4-methoxyphenyl)picolinamide(-1H))] 
• 1075281-21-8 [IrHCl(PPh₃)2(N-(4-methoxyphenyl)picolinamide(-1H))] 
• 1004265-88-6 [RuH(CO)(CH₃OC₆H₄NC(O)C₅H₄N)(P(C₆H₅)3)2] 
• 1004265-88-6 [RuH(CO)(CH₃OC₆H₄NC(O)C₅H₄N)(P(C₆H₅)3)2] 
• 96-96-8 4-methoxy-2-nitroaniline 
• 356539-11-2 4-[(4-methoxyphenyl)amino]butan-1-ol 

Relevant academic research and scientific papers

Solid-supported Pt-catalyzed remote C-H etherification of arylamines: A simple and practical approach for the synthesis of aromatic ethers

A simple and practical approach for a direct remote C-H etherification of arylamines with alcohol is developed herein by using a solid-supported Pt catalyst, hence providing a valuable method for the synthesis of aromatic ethers. The catalyst can easily b

Copper(ii) mediatedorthoC-H alkoxylation of aromatic amines using organic peroxides: efficient synthesis of hindered ethers

Synthesis of hindered alkyl aryl ether derivatives (R-O-Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired metabolic process and thus avoids rapid de

Copper-mediated ortho C–H primary amination of anilines

We report herein a copper-mediated ortho C–H primary amination of anilines by using cheap and commercially available benzophenone imine as the amination reagent. The protocol show good functional group tolerance and heterocyclic compatibility. Late-stage diversification of drugs demonstrate the synthetic utility of this protocol.

Solvent-free iron(III) chloride-catalyzed direct amidation of esters

Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.

Rh-Catalyzed Annulative Insertion of Terminal Olefin onto Pyridines via a C-H Activation Strategy Using Ethenesulfonyl Fluoride as Ethylene Provider

A Rh(III)-catalyzed annulative insertion of ethylene onto picolinamides was achieved, providing a portal to a class of unique pyridine-containing molecules bearing a terminal olefin moiety for diversification. Application of this method for modification of Sorafenib was also accomplished.

Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System

A practical copper-catalyzed, 2-picolinamide-directed ortho C-H amination of anilines with benzoyl-protected hydroxylamines has been disclosed that proceeds smoothly without any external stoichiometric oxidant or additives. Remarkably, besides anilines, b

Platinum(ii)-catalyzed selective: Para C-H alkoxylation of arylamines through a coordinating activation strategy

A highly efficient method to selectively install alkoxy onto the para position of arylamines via a coordinating activation strategy has been reported. Various substrates are compatible, providing the corresponding products in good to excellent yields. Thi

Transition-metal free oxidative C-H etherification of acylanilines with alcohols through a radical pathway

A transition metal free approach for the synthesis of methyl/ethyl aryl ether via oxidative C-H etherification of acylanilines with alcohols has been developed. Various acylanilines are compatible under standard conditions, giving the corresponding produc

An efficient and atom-economical route to: N -aryl amino alcohols from primary amines

In this paper we reported a novel method for generation of N-aryl amino alcohols from N,N-disubstituted picolinamides through reduction/ring-opening reaction with NaBH4. The N,N-disubstituted picolinamides can be easily obtained from primary am

Chelation-promoted Efficient C?H/N?H Cross Dehydrogenative Coupling between Picolinamides and Simple Ethers under Copper Catalysis

A highly efficient copper-catalyzed C?H/N?H cross dehydrogenative coupling between picolinamides and simple ethers was developed. The reaction was promoted by the chelation assistance of removable picolinyl group and exhibited excellent TON and TOF number. This method was applicable to both N-aryl and alkyl picolinamides as well as various cyclic and acyclic ethers with good functional group compatibility. It also possessed the merit of air and moisture tolerance and easy operation. (Figure presented.).