149923-10-4

Usage

Uses

4-Chlorobenzylzinc chloride used as a intermediate for pharmaceutical.

InChI:InChI=1/C7H6Cl.ClH.Zn/c1-6-2-4-7(8)5-3-6;;/h2-5H,1H2;1H;/q;;+1/p-1/rC7H6Cl2Zn/c8-7-3-1-6(2-4-7)5-10-9/h1-4H,5H2

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 7440-66-6 zinc 
• 7646-85-7 zinc(II) chloride 

Downstream Products

• 5925-80-4 1-chloro-4-((methylsulfonyl)methyl)benzene 
• 20025-49-4 4-chlorobenzyl 4'-methylphenyl sulfone 
• 51229-56-2 1-chloro-4-((phenylsulfonyl)methyl)benzene 
• 1359816-47-9 4-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline 
• 1471997-01-9 {(S)-6-[(R)-4-(4-chloro-benzyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester 
• 1359815-32-9 1-(4-chlorobenzyl)-3-nitro-6-(4-isopropoxyphenylamino)benzene 
• 1359817-93-8 1-(4-chlorobenzyl)-3-dimethyl-aminobenzene 
• 1359815-73-8 1-(4-chlorobenzyl)-3-dimethyl-amino-6-(3-fluoro-4-isopropoxyphenylamino)benzene 
• 1359817-94-9 6-bromo-1-(4-chlorobenzyl)-3-dimethyl-aminobenzene 
• 1401091-84-6 N-(2-(4-chlorophenyl)-1-(thiophen-2-yl)ethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 
• 1401091-82-4 N-(2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)ethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 
• 1401091-81-3 N-(2-(4-chlorophenyl)-1-(3,4,5-trimethoxyphenyl)ethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 
• 1401091-78-8 N-(2-(4-chlorophenyl)-1-phenylethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 
• 1401091-80-2 N-(2-(4-chlorophenyl)-1-(4-methoxyphenyl)ethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 

Relevant academic research and scientific papers

Asymmetric Synthesis of Fluorinated Allenes by Rhodium-Catalyzed Enantioselective Alkylation/Defluorination of Propargyl Difluorides with Alkylzincs

The reaction of propargyl difluorides R1CF2C≡CR2 with alkylzincs R3ZnCl giving axially chiral fluorinated allenes R1FC=C=CR2R3 with high enantioselectivity (up to 99 % ee) was found to be catalyzed by a chiral diene/rhodium complex. A key step in the catalytic cycle is selective elimination of one of the enantiotopic fluorides at the β-position of an alkenyl-Rh intermediate, which is generated by regioselective addition of R3-Rh onto the triple bond of the starting difluorides.

A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles

The Negishi palladium-catalyzed cross-coupling reaction between 3-ethoxy-4-iodo-1H-pyrazole and various benzylzinc halides was extensively studied. Using simplified, robust, and optimized reaction conditions, a series of electron-poor benzylzinc halides w

CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry. the Partner Organisations 2014.