5925-80-4

Usage

Physical state

Colorless liquid

Odor

Slightly sweet, pungent

Uses

a. Intermediate in the production of pharmaceuticals and agrochemicals
b. Synthesis of other organic compounds
c. Solvent in organic reactions
d. Reagent in organic reactions

Hazardous nature

Yes, considered a hazardous chemical

Precautions

Proper handling and storage required to ensure safety

Upstream product

• 3112-90-1 benzyl-methyl sulfone 
• 5925-82-6 (4-chlorobenzyl)(methyl)sulfane 
• 124-63-0 methanesulfonyl chloride 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 5925-67-7 methyl chlorobenzenethiocarboxylate 
• 74-83-9 methyl bromide 
• 43170-85-0 sodium (4-C₆H₄ClCH₂)(thiolate) 

Relevant academic research and scientific papers

Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides

Sulfonyl chlorides were reduced to anhydrous sulfinate salts with magnesium under sonication. These sulfinates were alkylated to sulfones with alkyl chlorides in the presence of catalytic sodium iodide under sonication. A variety of aliphatic sulfones was efficiently prepared by this one-pot two-step procedure.

CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry. the Partner Organisations 2014.

Azetidine derivatives, their preparation and medicaments containing them

The invention concerns compounds of formula (1) wherein: R represents a chain (A) or (B); R1 is methyl or ethyl; R2 is either an optionally substituted aromatic or an optionally substituted heteroaromatic ring; R3 and R4, identical or different, are either an optionally substituted aromatic or an optionally substituted heteroaromatic ring; R′ represents a hydrogen atom or a —CO—alk radical, their optical isomers, their salts, their preparation and medicines containing them.

BIOTRANSFORMATION OF ORGANIC SULFIDES. PART 6. FORMATION OF CHIRAL para-SUBSTITUTED BENZYL METHYL SULFOXIDES BY HELMINTHOSPORIUM SPECIES NRRL 4671

The fungus Helminthosporium species NRRL 4671 has been used for the biotransformation of a series of para-substituted benzyl sulfides with substituent groups consisting of trifluoromethyl, halo, hydroxy, methoxy, acetoxy, nitro, cyano, amino, acetamido, acyl and carboxylic acid units.In all cases, sulfoxide formation occurred in good yoeld and with predominant (S) chirality at the sulfur position.A minor amount of sulfone product was also obtained from the halo- and methoxy-substituted substrates.