20025-49-4

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 100716-85-6 4-chlorobenzyl 4-methylphenyl sulfide 
• 58680-48-1 C₇H₄Cl₂OS 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1950-78-3 p-toluenesulfonyl iodide 
• 622-95-7 4-chlorobenzyl bromide 
• 17530-79-9 1-chloro-4-((p-tolylsulfinyl)methyl)benzene 
• 873-76-7 para-Chlorobenzyl alcohol 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 200055-89-6 4-(4-toluenesulfonyloxy)coumarin 
• 31913-41-4 6-methyl-4-tosyloxy-2(2H)-pyranone 
• 536-57-2 p-toluene sulfinic acid 

Downstream Products

• 1372861-72-7 1-chloro-4-(1-tosylvinyl)benzene 
• 1563173-90-9 C₂₁H₁₆Cl₂O₂S 
• 1563173-95-4 C₃₃H₂₆O₂S 
• 1563174-09-3 C₂₇H₂₁ClO₂S 
• 1563174-10-6 C₂₇H₂₁ClO₂S 
• 72818-31-6 (4-Chlorobenzoyl)-4-tolyl-sulfon 
• 72826-83-6 C₁₆H₁₅ClO₃S 
• 20025-45-0 1--1--2-phenyl-aethan 

Relevant academic research and scientific papers

A new synthetic route to sulfones via activated nickel-assisted reactions of arenesulfonyl chlorides with active halides

Various sulfones were prepared in moderate yields by ultrasonic activated nickel-assisted coupling reactions of arenesulfonyl chlorides with alkyl halides.

Synthesis of sulfone derivatives via palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides

A palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides for the synthesis of various benzyl sulfones is reported. This novel protocol shows widespread functional group tolerance, leading to the desired sulfones in moderate to excellent yields.

Visible-Light-Catalyzed in Situ Denitrogenative Sulfonylation of Sulfonylhydrazones

A photocatalyzed in situ denitrogenative sulfonylation of N-arylsulfonyl hydrazones has been developed. This transformation provides a low-carbon strategy to assemble arylalkyl sulfones in a stepwise denitrogenation/sulfonylation manner.

Silver-Catalyzed C(sp3)-H Sulfonylation for the Synthesis of Benzyl Sulfones Using Toluene Derivatives and α-Amino Acid Sulfonamides

We describe a simple and practical protocol for the synthesis of benzyl sulfones using readily available toluene derivatives and α-amino acid sulfonamides. The reaction proceeds to afford a broad range of benzyl sulfones in moderate to high yields under silver catalysis. The mechanism possibly involves a Minisci-type formation of α-aminoalkyl radical, homolytic cleavage of a N-S bond to generate a sulfonyl radical, and coupling of sulfonyl radical with a benzyl radical formed via hydrogen abstraction by sulfate anion radical. The practicality of the present reaction is demonstrated by a gram-scale synthesis and one-step synthesis of anticancer-active compound. The mechanism studies are conducted using radical scavengers and deuterated toluene.

Efficient Synthesis of Sulfinate Esters and Sulfinamides via Activated Esters of p -Toluenesulfinic Acid

Sulfinate esters were prepared by the process of activating p -toluenesulfinic acid with either cyanuric chloride, methanesulfonyl chloride, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl). Activation of p -toluenesulfinic acid with cyanuric chloride led to the formation of sulfinate esters that were accompanied by the formation of the corresponding sulfones. The use of methanesulfonyl chloride for activation via methanesulfonic p -toluenesulfinic anhydride afforded mixtures of sulfinate esters and methanesulfonates. The use of the carbodiimide EDC proved to yield the best results with the highly selective formation of the target sulfinate esters. The use of trimethylacetic p -toluenesulfinic anhydride or cyanuric chloride to achieve the synthesis of sulfinamides proved to be ineffective due to poor chemoselectivity of the nucleophilic attack on the activated p -toluenesulfinic acid anhydride. Ultimately, the use of EDC-HCl to form the sulfinamides proved to be the best pathway for synthesis.

Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides

Sulfonyl chlorides were reduced to anhydrous sulfinate salts with magnesium under sonication. These sulfinates were alkylated to sulfones with alkyl chlorides in the presence of catalytic sodium iodide under sonication. A variety of aliphatic sulfones was efficiently prepared by this one-pot two-step procedure.

Iron(III) phthalocyanine-chloride-catalyzed synthesis of sulfones from sulfonylhydrazones

In this study, sulfones are synthesized from sulfonylhydrazones catalyzed by iron(III) phthalocyanine chloride. This reaction offers broad substrate scope, occurs under mild conditions, utilized readily available reactants, and forms products in good-to-h

CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry. the Partner Organisations 2014.

Asymmetric synthesis of aryl benzyl sulfoxides by vanadium-catalysed oxidation: A combination of enantioselective sulfide oxidation and kinetic resolution in sulfoxide oxidation

Enantioselective vanadium-catalysed oxidation of aryl benzyl sulfides using Bolm's procedure is accompanied by kinetic resolution in the oxidation of the resulting sulfoxides which enhances the enantiopurities of the sulfoxides recovered (typically >90% ee), albeit with an associated reduction in yield. The effects of ligand, solvent and reaction conditions are discussed in detail. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Kinetic resolution in vanadium-catalyzed sulfur oxidation as an efficient route to enantiopure aryl benzyl sulfoxides

Enantiopure aryl benzyl sulfoxides can be prepared using vanadium-Schiff base catalyzed sulfide oxidation and kinetic resolution of the resulting sulfoxide. The kinetic resolution can be effected in combination with asymmetric sulfide oxidation or instead starting from the racemic sulfoxide. Georg Thieme Verlag Stuttgart.