20025-49-4

Basic information

• Product Name: 1-[(4-chlorobenzyl)sulfonyl]-4-methylbenzene
• Synonyms: 1-[(4-chlorobenzyl)sulfonyl]-4-methylbenzene
• CAS NO: 20025-49-4
• Molecular Formula: C₁₄H₁₃ClO₂S
• Molecular Weight: 280.76982
• Mol File: 20025-49-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(4-chlorobenzyl)sulfonyl]-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-chlorobenzyl)sulfonyl]-4-methylbenzene(20025-49-4)
• EPA Substance Registry System: 1-[(4-chlorobenzyl)sulfonyl]-4-methylbenzene(20025-49-4)

Safety Data

• Hazardous Substances Data: 20025-49-4(Hazardous Substances Data)

Upstream product

• 58680-48-1 C₇H₄Cl₂OS 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1950-78-3 p-toluenesulfonyl iodide 
• 622-95-7 4-chlorobenzyl bromide 
• 100716-85-6 4-chlorobenzyl 4-methylphenyl sulfide 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 536-57-2 p-toluene sulfinic acid 
• 873-76-7 para-Chlorobenzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 31913-41-4 6-methyl-4-tosyloxy-2(2H)-pyranone 
• 200055-89-6 4-(4-toluenesulfonyloxy)coumarin 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 

Downstream Products

• 72826-83-6 C₁₆H₁₅ClO₃S 
• 1563173-90-9 C₂₁H₁₆Cl₂O₂S 
• 1563173-95-4 C₃₃H₂₆O₂S 
• 1563174-09-3 C₂₇H₂₁ClO₂S 
• 1563174-10-6 C₂₇H₂₁ClO₂S 
• 1372861-72-7 1-chloro-4-(1-tosylvinyl)benzene 
• 20025-45-0 1--1--2-phenyl-aethan 
• 72818-31-6 (4-Chlorobenzoyl)-4-tolyl-sulfon 

Relevant articles and documents

A new synthetic route to sulfones via activated nickel-assisted reactions of arenesulfonyl chlorides with active halides

Various sulfones were prepared in moderate yields by ultrasonic activated nickel-assisted coupling reactions of arenesulfonyl chlorides with alkyl halides.

Synthesis of sulfone derivatives via palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides

A palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides for the synthesis of various benzyl sulfones is reported. This novel protocol shows widespread functional group tolerance, leading to the desired sulfones in moderate to excellent yields.

Efficient Synthesis of Sulfinate Esters and Sulfinamides via Activated Esters of p -Toluenesulfinic Acid

Sulfinate esters were prepared by the process of activating p -toluenesulfinic acid with either cyanuric chloride, methanesulfonyl chloride, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl). Activation of p -toluenesulfinic acid with cyanuric chloride led to the formation of sulfinate esters that were accompanied by the formation of the corresponding sulfones. The use of methanesulfonyl chloride for activation via methanesulfonic p -toluenesulfinic anhydride afforded mixtures of sulfinate esters and methanesulfonates. The use of the carbodiimide EDC proved to yield the best results with the highly selective formation of the target sulfinate esters. The use of trimethylacetic p -toluenesulfinic anhydride or cyanuric chloride to achieve the synthesis of sulfinamides proved to be ineffective due to poor chemoselectivity of the nucleophilic attack on the activated p -toluenesulfinic acid anhydride. Ultimately, the use of EDC-HCl to form the sulfinamides proved to be the best pathway for synthesis.