15017-32-0

Basic information

• Product Name: 4-Pyridinecarboxylicacid, 2-(2-pyridinylmethylene)hydrazide
• Synonyms: 4-Pyridinecarboxylicacid, (2-pyridinylmethylene)hydrazide (9CI); Isonicotinic acid, (2-pyridylmethylene)hydrazide(6CI,7CI,8CI); Hydrazine, 1-isonicotinoyl-2-(2-pyridylmethylene)- (6CI);2-Pyridinealdehyde isonicotinoylhydrazone; 2-Pyridinecarbaldehydeisonicotinoylhydrazone; 2-Pyridinecarboxaldehyde isonicotinoyl hydrazone;2-Pyridylaldehyde isonicotinoylhydrazone; 2-Pyridylcarboxaldehyde isonicotinoylhydrazone; NSC 690252; NSC 76233
• CAS NO: 15017-32-0
• Molecular Formula: C12H10 N4 O
• Molecular Weight: 226.234
• Mol File: 15017-32-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.22g/cm³
• CAS DataBase Reference: 4-Pyridinecarboxylicacid, 2-(2-pyridinylmethylene)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylicacid, 2-(2-pyridinylmethylene)hydrazide(15017-32-0)
• EPA Substance Registry System: 4-Pyridinecarboxylicacid, 2-(2-pyridinylmethylene)hydrazide(15017-32-0)

Safety Data

• Hazardous Substances Data: 15017-32-0(Hazardous Substances Data)

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 1121-60-4 pyridine-2-carbaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 55-22-1 pyridine-4-carboxylic acid 
• 54-85-3 isoniazid 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 257299-41-5 (Z)-N'-(pyridin-2-ylmethylene)isonicotinic hydrazide 
• 6885-17-2 diacetoxy-pyridin-2-yl-methane 

Downstream Products

• 1257241-62-5 Pb⁽²⁺⁾*C₅H₄NCONNCHC₅H₄N^(1-)*HOC₆H₄COO^(1-)=Pb(C₅H₄NCONNCHC₅H₄N)(HOC₆H₄COO) 
• 257299-41-5 (Z)-N'-(pyridin-2-ylmethylene)isonicotinic hydrazide 

Relevant articles and documents

Synthesis, structural characterization, and molecular docking studies of bioactive bismuth(III) complexes with substituted hydrazones

Eight new bismuth(III) complexes (1-8) of substituted hydrazones having general formula; [Bi(RCONHNCHC5H4N)Clx] and [Bi(RCONHNCHC9H6N)Clx], where R = C10H7O (1, and 8)

Syntheses, characterization and crystal structures of potassium and barium complexes of a Schiff base ligand with different anions

New pseudopolymorph of a O,N,N'-donor hydrazone ligand, 2-pyridylcarboxaldehyde isonicotinoylhydrazone (L) and its discrete complexes with K+ and Ba2+ have been reported. L forms isostructural dinuclear complexes with K+ when bromide and iodide were employed as counter anions. However, a monomeric complex in the case of Ba2+ with existence of coordinated as well as lattice perchlorate counter anions was observed. All compounds were characterized by single crystal X-ray analysis and other physicochemical techniques. Structural analysis and spectral features of all compounds are described in detail.

Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation

Acylhydrazones 1a-o, derived from isoniazid, were synthesized and evaluated for Myeloperoxidase (MPO) and Acetylcholinesterase (AChE) inhibition, as well as their antioxidant and metal chelating activities, with the purpose of investigating potential multi-target profiles for the treatment of Alzheimer's disease. Synthesized compounds were tested using the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method and 1i, 1j and 1 m showed radical scavenging ability. Compounds 1b, 1 h, 1i, 1 m and 1o inhibited MPO activity (10 μM) at 96.1 ± 5.5%, 90 ± 2.1%, 100.3 ± 1.7%, 80.1 ± 9.4% and 82.2 ± 10.6%, respectively, and only compound 1 m was able to inhibit 54.2 ± 1.7% of AChE activity (100 μM). Docking studies of the most potent compound 1 m were carried out, and the computational results provided the theoretical basis of enzyme inhibition. Furthermore, compound 1 m was able to form complexes with Fe2+ and Zn2+ ions in a 2:1 ligand:metal ratio according to the Job Plot method.

Synthesis, crystal structures, characterization and catalytic property of manganese(II) complexes derived from hydrazone ligands

A new bromido-coordinated mononuclear manganese(II) complex [MnL1Br2(OH2)] (1), and a new nitrato-coordinated mononuclear manganese(II) complex [Mn(L2)2(ONO2)(OH2)]NO3