150258-79-0Relevant academic research and scientific papers
Photoisomerization of stilbene dendrimers: The need for a volume-conserving isomerization mechanism
Uda, Mayuko,Mizutani, Takuo,Hayakawa, Junpei,Momotake, Atsuya,Ikegami, Masashi,Nagahata, Ritsuko,Arai, Tatsuo
, p. 596 - 605 (2002)
Highly branched stilbene dendrimers were synthesized and their photochemical behavior was studied. Even the stilbene dendrimer with molecular weight over 6500 underwent transcis isomerization in the excited singlet state within the lifetime of 10 ns. The
Synthesis and Protein-Tyrosine Kinase Inhibitory Activity of Polyhydroxylated Stilbene Analogues of Piceatannol
Thakkar, Kshitij,Geahlen, Robert L.,Cushman, Mark
, p. 2950 - 2955 (2007/10/02)
A series of hydroxylated trans-stilbene related to the antileukemic natural product trans-3,3',4,5'-tetrahydroxy stilbene (piceatannol) (1) has been prepared and tested for inhibition of the lymphoid cell lineage-specific protein-tyrosine kinase p56lck, which plays an important role in lymphocyte proliferation and immune function.A number of the analogues displayed enhanced enzyme inhibitory activity relative to the natural product.Reduction of the double bond bridging the two aromatic rings and benzylation of the phenolic hydroxyl groups was found to decrease activity significantly.The most potent compounds in the series proved to be trans-3,3',5,5'-tetrahydroxystilbene, trans-3,3',5-trihydroxystilbene, and trans-3,4,4'-trihydroxystilbene.
