150296-35-8

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 98-86-2 acetophenone 
• 58059-08-8 tert-butyl (R)-p-toluenesulfinylacetate 
• 51656-70-3 (2-tert-butoxy-2-oxoethyl)zinc(II) bromide 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 63741-24-2 α-(p-tolylsulfinyl) β-hydroxy β-phenyl n-butanoate de t-butyle 

Relevant academic research and scientific papers

Enantioselective reformatsky reaction induced by chiral β-amino alcohols

Reformatsky reagent derived from tert-butyl α-bromoacetate adds to carbonyl compounds in the presence of chiral amino alcohols leading to β-hydroxy tert-butyl eaters with good e.e. The enantioface differentiation depends on the reaction conditions and on

Enantioselective Reformatsky Reaction with Ketones. Asymmetric Synthesis of β-(tert-Hydroxy)esters

Optically active β-(tert-hydroxy)esters with good enantiomeric excesses (up to 75percent e.e.) are synthesised via enantioselective Reformatsky reaction with ketones in the presence of chiral N,N-dialkylnorephedrine.

SYNTHESES ASYMETRIQUES DE β-HYDROXYACIDES PAR CONDENSATION D'ANIONS ENOLATES D'ESTERS α-SULFINYLE CHIRAUX SUR DES COMPOSES CARBONYLES

A stereospecific synthesis of (R)-(+)-t-butyl p-tolylsulfinyl acetate 2 is described.The aldol-type condensation of this reagent leads to β-hydroxyacids in good chemical and optical yields.The determination of the absolute configuration of the condensatio