150356-88-0

Upstream product

• 75-15-0 carbon disulfide 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 1004-40-6 6-Amino-2-thiouracil 

Downstream Products

• 1310089-66-7 6-(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-75-8 3-benzylsulphanyl-6-(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-73-6 6-(4-chlorophenyl)-3-methylsulphanyl-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-68-9 6-(4-chlorophenyl)-5-oxo-8-phenyl-1H-pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-thione 
• 1310089-67-8 6-(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidin-3,5(2H)-dione 
• 1310089-72-5 6-(4-chlorophenyl)-3-ethyl-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-78-1 5-(4-chlorophenyl)-2-((3-nitrophenyl)methylenehydrazinyl)-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 1310089-71-4 6-(4-chlorophenyl)-3-methyl-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-77-0 2-((4-chlorophenyl)methylenehydrazinyl)-5-(4-chlorophenyl)-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 1310089-74-7 6-(4-chlorophenyl)-3-ethylsulphanyl-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-65-6 5-(4-chlorophenyl)-2-hydrazino-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 1310089-69-0 3-amino-6-(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-82-7 6-(4-chlorophenyl)-3-(3-nitrophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 
• 1310089-81-6 3,6-di(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one 

Relevant academic research and scientific papers

Focused microwave-assisted efficient and convenient synthesis of new pyrido[2,3-d] pyrimidinone derivatives

A rapid and efficient method for the preparation of new pyrido[2,3-d]pyrimidinone derivatives by the condensation of 2-amino-4-aryl-6-arylnicotinamides with carbon disulfide or cycloalkanones under focused microwave irradiation is described.

Synthesis and antitumor activity of novel pyrido[2,3-d][1,2,4]triazolo[4,3- a]pyrimidin-5-one derivatives

A series of new pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidines with different substituents at position 3 were synthesized. The effect of the newly synthesized compounds was tested in vitro on human breast adenocarcinoma cell line (MCF7). Some of the synthesized compounds exploited potent antitumor activity, especially the 3-amino derivative 12 which displayed the highest activity among the test compounds with IC50 equal to 3.74 μg/mL.