150360-25-1

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-(3-fluorophenyl)propanoic acid is used as a precursor for the synthesis of various drugs due to its unique properties and potential interactions with biological targets.
Used in Research and Development:
(R)-2-(3-fluorophenyl)propanoic acid is used as a research compound for studying its pharmacological applications and potential therapeutic effects, particularly in the development of new drugs and therapies.
Used in Chemical Synthesis:
(R)-2-(3-fluorophenyl)propanoic acid is used as a building block in the synthesis of more complex organic molecules, leveraging its unique properties and reactivity.
Used in Drug Design:
(R)-2-(3-fluorophenyl)propanoic acid is used as a key component in the design of novel drugs, taking advantage of its stereochemistry and potential to interact with specific biological targets for therapeutic purposes.
Used in Chiral Chemistry:
(R)-2-(3-fluorophenyl)propanoic acid is used in chiral chemistry to study the effects of stereochemistry on compound properties and reactivity, which is crucial for understanding the behavior of enantiomers in biological systems and drug development.

Upstream product

• 64-18-6 formic acid 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 201230-82-2 carbon monoxide 
• 350-51-6 3-fluorostyrene 
• 145983-05-7 α-(m-fluorophenyl)-α-methylmalonic acid 
• 64123-77-9 methyl (3-fluorophenyl)acetate 

Relevant academic research and scientific papers

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens

We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.

Simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and methoxycarbonylation of vinyl arenes

Using a family of novel mononuclear and dinuclear palladium complexes of phanephos ligands, the simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and alkoxycarbonylation of styrene derivatives has been realised for the first time. The Royal Society of Chemistry 2013.

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids.Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing.Decarboxylation of α-fluoro-α-phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro-α-phenylacetic acid.