1505-62-0

Usage

Uses

Used in Pharmaceutical Industry:
5-METHYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of bioactive molecules for various therapeutic applications. Its unique structure allows it to be a key component in the development of new drugs with diverse pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical sector, 5-METHYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID serves as an intermediate in the production of pesticides. Its incorporation into these compounds can enhance their pesticidal properties, making them more effective in controlling pests and diseases in agriculture.
Used in Organic Compounds Production:
5-METHYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID is used as a building block in the creation of organic compounds with a range of therapeutic and pesticidal properties. Its versatility in chemical reactions enables the synthesis of a variety of compounds with potential applications in medicine and agriculture.
Used in Medicinal Chemistry and Chemical Biology Research:
Due to its potential biological activities, 5-METHYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID is a target for further research and development in medicinal chemistry and chemical biology. Its exploration can lead to the discovery of new bioactive compounds and a better understanding of their mechanisms of action.

InChI:InChI=1/C10H8O2S/c1-6-2-3-8-7(4-6)5-9(13-8)10(11)12/h2-5H,1H3,(H,11,12)

Upstream product

• 14315-14-1 5-methylthianaphthene 
• 124-38-9 carbon dioxide 
• 82787-69-7 5-methylbenzothiophene-2-carboxylic acid methyl ester 
• 93249-44-6 2-fluoro-5-methylbenzaldehyde 
• 13616-73-4 5-methyl-2-methylthiobenzaldehyde 
• 2046-77-7 2-acetyl-5-methylbenzo[b]thiophene 
• 101219-39-0 ethyl 5-methylbenzo[b]thiophene-2-carboxylate 

Downstream Products

• 14315-14-1 5-methylthianaphthene 
• 852668-51-0 C₂₄H₂₄N₄O₃S 
• 82787-69-7 5-methylbenzothiophene-2-carboxylic acid methyl ester 
• 82788-51-0 5-Imidazol-1-ylmethyl-benzo[b]thiophene-2-carboxylic acid 
• 82787-71-1 5-(1-imidazolylmethyl)benzo[b]thiophene-2-carboxylic acid methyl ester 
• 82787-70-0 methyl 5-(bromomethyl)benzo[b]thiophene-2-carboxylate 

Relevant academic research and scientific papers

SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Benzo[b]thiophene-2-carboxamide derivatives as potent urotensin-II receptor antagonists

Members of a series of benzo[b]thiophene-2-carboxamide derivatives, possessing an N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl) group, were synthesized and evaluated as urotensin-II receptor antagonists. The results show that these substances have potent UT binding affinities. Observations made in a systematic SAR investigation of the effects of a variety of substituents (R1and R2) at the 5- and 6-positions in the benzo[b]thiophene-2-carboxamide moiety on UT binding affinities led to identification of the 5-cyano analog 7f as a highly potent UT antagonist with an IC50value of 25?nM. Despite having a good metabolic stability, 7f is a potent inhibitor of CYP isozyme and displays an unsuitable PK profile.

GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Benzimidazole derivative

The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Benzimidazole derivatives

A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: 1wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents —COOR3, —SO3R3, —CONHR3 or —SO2NHR3, etc., G represents an alkylene group, M represents a single bond or —S(O)m. J represents a heterocyclic group, and X represents —CH= or a nitrogen atom.

(Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives

Compounds of formula (I) wherein R is hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF.

BENZIMIDAZOLE DERIVATIVES

A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents -COOR3, -SO3R3, -CONHR3 or -SO2NHR3, etc., G represents an alkylene group, M represents a single bond or -S(O)m-, J represents a heterocyclic group, and X represents -CH= or a nitrogen atom.

Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure

The invention relates to compounds of the formula I STR1 in which X, Y and Z are identical or different and are N or CR 2, R 1 and R 2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.