82787-69-7

Usage

InChI:InChI=1/C11H10O2S/c1-7-3-4-9-8(5-7)6-10(14-9)11(12)13-2/h3-6H,1-2H3

Upstream product

• 67-56-1 methanol 
• 1505-62-0 5-methyl-benzo[b]thiophene-2-carboxylic acid 
• 106-45-6 para-thiocresol 
• 14315-14-1 5-methylthianaphthene 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 93249-44-6 2-fluoro-5-methylbenzaldehyde 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 82787-70-0 methyl 5-(bromomethyl)benzo[b]thiophene-2-carboxylate 
• 1505-62-0 5-methyl-benzo[b]thiophene-2-carboxylic acid 
• 82788-51-0 5-Imidazol-1-ylmethyl-benzo[b]thiophene-2-carboxylic acid 
• 82787-71-1 5-(1-imidazolylmethyl)benzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6

We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C?H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.

HETEROCYCLIC DERIVATIVES AND USE THEREOF

A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated

Benzo[b]thiophene-2-carboxamide derivatives as potent urotensin-II receptor antagonists

Members of a series of benzo[b]thiophene-2-carboxamide derivatives, possessing an N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl) group, were synthesized and evaluated as urotensin-II receptor antagonists. The results show that these substances have potent UT binding affinities. Observations made in a systematic SAR investigation of the effects of a variety of substituents (R1and R2) at the 5- and 6-positions in the benzo[b]thiophene-2-carboxamide moiety on UT binding affinities led to identification of the 5-cyano analog 7f as a highly potent UT antagonist with an IC50value of 25?nM. Despite having a good metabolic stability, 7f is a potent inhibitor of CYP isozyme and displays an unsuitable PK profile.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with a compound represented by the following Formula (1): provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (8) is excluded: (1) Methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (2) Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (3) Methyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (4) Methyl 7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (5) Ethyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (6) Ethyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (7) Ethyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, and (8) Ethyl 7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate.

Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them

Heterocyclic thromboxane synthetase inhibitors of the formula STR1 wherein R1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C1 -C4 alkyl, hydroxy or C1 -C4 alkoxy; Y, which is attached to the 2- or 3-position, is --COOH, --COO(C1 -C4 alkyl) or --CONH2 ; X is O, S, NH, N(C1 -C4 alkyl) or N(benzyl); and R, which is attached to the 5-, 6- or 7-position, is a group of the formula STR2 or (3- or 4-pyridyl)-Z2 - wherein Z1 is --CH2 --, --CH2 CH2 -- or --CH2 CH2 O-- and Z2 is --CH2 --, --CH2 CH2 --, --CH=CH--, --CH2 O-- or --OCH2 --; and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them.