15059-17-3

Upstream product

• 52188-11-1 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid 
• 62-53-3 aniline 
• 10332-51-1 potassium saccharate 
• 61020-33-5 2-[1,1-dioxide-3-oxo-1,2-benzisothiazole-2(3H)-yl] acetic acid chloride 
• 128-44-9 saccharin sodium salt 
• 587-65-5 N-chloroacetyl-aniline 
• 15059-15-1 2-(2-(Z)-hydroxyimino-2-phenyl-ethyl)-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 

Downstream Products

• 86048-59-1 2-(Phenylcarbamoylmethyl-sulfamoyl)-benzoic acid methyl ester 
• 86048-63-7 0-(N-phenylcarboxamidomethylsulfamyl)benzoic acid 
• 35511-01-4 1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-3-carboxylic acid anilide 

Relevant academic research and scientific papers

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Large, diverse compound libraries are an essential requisite in target-based drug development. In this work, a robust microwave-assisted synthesis for the diastereoselective generation of 3-saccharinyl-trans-β-lactams is reported. The method is optimised

PEG-600 mediated facile and green synthesis of novel imide derivatives and their biological activity evaluation

Facile and green syntheses of novel 2-(1,2-benzisothiazole-3-one-1,1- dioxide)-N-arylacetamides, 2-(1,3- dioxoisoindolin-2-yl)-N-arylacetamides and 2-(N-(2-oxo-2-(arylamino)ethyl)sulfamoyl (or) carbamoyl)benzoic acids have been developed and tested for th

Synthesis of some saccharin derivatives of expected biological activity based on n-(saccharinyl)-acetic acidazide

Azide 3 was prepared from the corresponding acid chloride 2. The base catalyzed decomposition with aromatic amines, aminobenzoic acids and/or hydrazines afforded the corresponding anilides 4a-f and/or hydrazides 5a-d via azido group displacement. Compounds 5c and 5d were refluxed in Ac2O to give 1,3,4-oxadiazole derivatives 6a and 6b. Lewis acid catalyzed decomposition of azide 3 with anhyd. AlCl3 in dry aromatic substrates gave the corresponding ketones 7a-c. Also, the reaction of azide 3 with glycine gave 9.

Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides

A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, STR1 wherein R1 is hydrogen or lower alkyl and R2 is lower alkyl, aryl or a heterocyclic ring selected from the group consisting of pyridyl, substituted-pyridyl, and thiazolyl. Compounds of the formula II have useful anti-inflammatory properties. In addition, they can be used as intermediate in the preparation of known anti-inflammatory agents.