150660-28-9

Upstream product

• 22145-08-0 (E,E)-1-(4-methoxyphenyl)-4-phenyl-1,3-butadiene 
• 104-53-0 3-phenyl-propionaldehyde 
• 1530-38-7 ((4-methoxyphenyl)methyl)triphenylphosphonium bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 689258-74-0 (E)-tert-butyl((4-(4-methoxyphenyl)but-3-en-1-yl)oxy)dimethylsilane 
• 1384458-50-7 (E)-4-(4-methoxyphenyl)but-3-en-1-yl 4-methylbenzenesulfonate 
• 98-80-6 phenylboronic acid 
• 92587-78-5 trans-4-(p-methoxyphenyl)-3-buten-1-ol 
• 696-62-8 para-iodoanisole 
• 184370-59-0 (E)-1-iodo-4-phenyl-1-butene 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 133595-52-5 diethyl 2,6-dimethyl-4-phenethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 39110-26-4 (triphenylphosphonio)-3-phenyl-1-propanide 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1191292-87-1 2-(4-methoxyphenyl)-1-(4-nitrobenzenesulfonyl)-3-phenylethylaziridine 
• 38841-95-1 1-(p-methoxyphenyl)-4-phenylbutane 
• 19353-89-0 1-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalene 
• 1314987-58-0 N-[1-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

Regio- and Enantioselective Decarboxylative Allylic Benzylation Enabled by Dual Palladium/Photoredox Catalysis

A decarboxylative allylic benzylation cocatalyzed by Pd/photoredox in a regio- and enantioselective manner has been achieved. Readily available aryl acetic acids are used as benzylic nucleophile equivalents without preactivation. This mild and atom-economical protocol expands the scope of coupling partners of allylic electrophiles. Vinyl epoxides could also go through this transformation smoothly, affording various chiral homoallylic alcohols bearing all-carbon quaternary stereocenters.

Visible Light-Driven, Room Temperature Heck-Type Reaction of Alkyl Halides with Styrene Derivatives Catalyzed by B12 Complex

A visible light driven Heck-type coupling reaction of alkyl halides with styrene and its derivatives catalyzed by the cobalamin derivative (B12) with the [Ru(bpy)3]Cl2 photosensitizer at room temperature is reported. The catalytic efficiencies of the B12 catalyst were compared to that of other cobalt complexes such as cobaloxime. Various control experiments supported a radical-based mechanism similar to those for typical B12 model reactions. A unique coupling reaction combined with 1,2-migration of the functional group is also reported. Mild reaction conditions using an environmentally benign cobalt catalyst derived from the natural B12 provided a practical protocol for the synthetic organic chemistry of the B12 catalyzed reaction system. (Figure presented.).

RETRACTED ARTICLE: Copper-Catalyzed Decarboxylative C(sp2)-C(sp3) and C(sp)-C(sp3) Coupling of Substituted Cinnamic Acids and 3-Phenyl Propiolic Acid with N-Tosyl Oxaziridines

A mild and efficient strategy for decarboxylative C(sp2)-C(sp3) and C(sp)-C(sp3) coupling of α,β-unsaturated carboxylic acids such as substituted cinnamic acids and 3-phenyl propiolic acid with N-Tosyl oxaziridines was developed. The corresponding products were achieved in moderate to good yields with excellent stereoselectivity. Base-free and oxidant-free conditions allow good functional group tolerance. Radical inhibitors such as TEMPO and BHT completely suppressed the reactions suggesting a radical mechanism was involved. This study is supposed to broaden the frontier of oxaziridines' chemistry and to open up a novel cascade for alkylating reagents.

Enantioselective Allylic Alkylation with 4-Alkyl-1,4-dihydro-pyridines Enabled by Photoredox/Palladium Cocatalysis

Highly regio- and enantioselective allylic alkylation has been achieved enabled by the merger of photoredox and palladium catalysis. In this dual catalytic process, alkyl radicals generated from 4-alkyl-1,4-dihydropyridines act as the coupling partners of the π-allyl palladium complexes. The generality of this method has been illustrated through the reaction of a variety of allyl esters with 4-alkyl-1,4-dihydropyridines. This mechanistically novel strategy expands the scope of the traditional Pd-catalyzed asymmetric allylic alkylation reaction and serves as its alternative and potential complement.

Design, Synthesis, and Application of Polymer-Supported Silicon-Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents

The initial design, synthesis, and validation of polymer-supported siloxane transfer agents have been achieved that permit the direct use of organolithium reagents in the palladium-catalyzed cross-coupling reactions. Through rational design, two generations of polymer support were developed that significantly simplify product purification and the transfer agent recycling.

SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Alkyl transfer from C-C cleavage: Replacing the nitro group of nitro-olefins

Alkyl substituted Hantzsch esters are rationally used as alkylation reagents to replace the nitro groups of nitro olefins to give excellent yields of trans-olefins. The reaction mechanism is considered to proceed through a free radical mechanism, which is different from the corresponding transfer alkylation of imines. This journal is the Partner Organisations 2014.

Recyclable polystyrene-supported siloxane-transfer agent for palladium-catalyzed cross-coupling reactions

The rational design, synthesis, and validation of a significantly improved insoluble polymer-supported siloxane-transfer agent has been achieved that permits efficient palladium-catalyzed cross-coupling reactions. The cross-linked polystyrene support facilitates product purification with excellent siloxane recycling. Drawbacks of a previous polymer-supported siloxane-transfer agent, relating to reaction efficiency and polymer stability after repeated cycles, have been addressed.

Preparation and palladium-mediated cross-coupling of α- benzoyloxyalkylzinc bromides

Here we report a two-step preparation protocol of α- benzoyloxyalkylzinc bromides from α-benzoyloxyalkyl selenides, and their application to palladium-catalyzed cross-coupling reactions with aryl and vinyl iodides. The developed method effectively provides a variety of benzoyl-protected benzylic and allylic alcohol derivatives through the formation of C(sp3)-C(sp2) bonds without affecting various polar functional groups.

Polymer-supported siloxane transfer agents for Pd-catalyzed cross-coupling reactions

The design, synthesis, and validation of a ring-opening metathesis polymerization (ROMP) polymer supporting siloxane transfer agents have been achieved that permit efficient palladium-catalyzed cross-coupling reactions. The solubility properties of the polymer facilitate not only product purification but also polymer recycling without significant loss of cross-coupling activity.