1539-57-7

Usage

Uses

Used in Pharmaceutical Applications:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's due to its potential neuroprotective properties. Its unique structure may contribute to its ability to mitigate oxidative stress and inflammation, which are key factors in the progression of such diseases.
Used in Antioxidant Formulations:
As an antioxidant, 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used to protect cells from oxidative damage, which is a common pathological feature in many diseases and conditions. Its antioxidant properties may be leveraged in the development of pharmaceuticals and supplements to combat oxidative stress.
Used in Anti-Inflammatory Agents:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used as an anti-inflammatory agent, potentially reducing inflammation in various conditions. Its structure may allow it to modulate inflammatory pathways, offering a new approach to treating inflammatory diseases.
Used in Agrochemical Development:
In the agrochemical industry, 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester may be used as a component in the development of new pesticides or herbicides. Its chemical properties could provide novel modes of action against pests and weeds, enhancing crop protection strategies.
Used in Materials Science:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester's unique structure may also find applications in materials science, potentially serving as a component in the development of new polymers or other materials with specific properties, such as improved stability or reactivity.

InChI:InChI=1/C20H25NO4/c1-5-24-19(22)17-13(3)21-14(4)18(20(23)25-6-2)16(17)12-15-10-8-7-9-11-15/h7-11,16,21H,5-6,12H2,1-4H3

Upstream product

• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 140429-21-6 N-(1-chloro-2-phenylethyl)pyridinium chloride 
• 122-78-1 phenylacetaldehyde 
• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 626-34-6 ethyl aminocrotonate 
• 36873-30-0 2-benzyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 

Downstream Products

• 1149-24-2 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester 
• 65-85-0 benzoic acid 
• 16035-87-3 N-(p-nitrobenzyl)-p-anisidine 
• 1834-74-8 (1,2-diphenyl-ethyl)-(4-methoxy-phenyl)amine 
• 436087-20-6 N-(1-(furan-2-yl)-2-phenylethyl)-4-methoxyaniline 
• 35856-81-6 1-methoxy-4-[(1E)-3-phenylprop-1-en-1-yl]benzene 
• 1609469-10-4 C₁₃H₁₇NO₄*HNO₂ 
• 1191300-32-9 (E)-1-(3-bromophenyl)-3-phenylpropene 
• 183621-32-1 (E)-1-fluoro-4-(3-phenylprop-1-en-1-yl)benzene 
• 5751-28-0 (E)-1-(3-phenylprop-1-en-1-yl)naphthalene 

Relevant academic research and scientific papers

Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis

An enantioselective addition reaction of various alkyl groups to unactivated internal alkenes under Cu catalysis has been developed. The reaction uses amide-linked aminoquinoline as the directing group, 4-alkyl Hantzsch esters as the donor of alkyl radicals, and rarely used biaryl diphosphine oxide as a chiral ligand. β-lactams featuring two contiguous stereocenters at Cβ and the β substituent can be obtained in good yield with excellent enantioselectivity. Mechanistic studies indicate that a nucleophilic addition of the alkyl radical to CuII-coordinated alkene is the enantio-determining step.

Visible-light-mediated minisci C-H alkylation of heteroarenes with 4-alkyl-1,4-dihydropyridines using O2as an oxidant

Herein, we report a protocol for direct visible-light-mediated Minisci C-H alkylation reactions of N-heteroarenes with 4-alkyl-1,4-dihydropyridines at room temperature with molecular oxygen as an oxidant. The protocol permits efficient functionalization of various N-heteroarenes with a broad range of cyclic and acyclic primary, secondary, and tertiary alkyl groups and is scalable to the gram level. This mild protocol uses an inexpensive, green oxidant and is suitable for late-stage C-H alkylation of complex nitrogen-containing molecules. We demonstrated its utility by preparing or functionalizing several pharmaceuticals and natural products.

USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.

Unprecedented synthesis of hantzsch 1,4-dihydropyridines under biginelli reaction conditions

Hantzsch 1,4-dihydropyridines are synthesized in high yields by a one-pot cyclocondensation of aldehyde, β-ketoester, and urea on the surface of silica gel under microwave irradiation in solvent-free conditions.

Novel syntheses of heterocycles with N-(1-haloalkyl)azinium halides. Part 2. Preparation of N-unsubstituted 1,4-dihydropyridines

N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and aldehydes, readily react with enaminocarbonyl derivatives to yield 1,4-dihydropyridines under mild and neutral conditions.

CARBON TRANSFER REACTIONS WITH HETEROCYCLES-V. A FACILE SYNTHESIS OF NIFEDIPINE AND ANALOGUES

Oxazolidines and tetrahydro-(2H)-1,3-oxazines transfer their C(2) units at the carbonyl group oxidation level to alkyl-β-amino/anilinocrotonates to form 1,4-dihydropyridines elaborated at C-4.