1539-57-7

Basic information

• Product Name: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester
• Synonyms: 1,4-Dihydro-2,6-dimethyl-4-benzyl-3,5-pyridinedicarboxylic acid diethyl ester;1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester;2,6-Dimethyl-4-benzyl-1,4-dihydro-3,5-pyridinedicarboxylic acid diethyl ester;2,6-Dimethyl-4-benzyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester;4-Benzyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• CAS NO: 1539-57-7
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.4168
• Mol File: 1539-57-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 460.3°Cat760mmHg
• Flash Point: 232.2°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 1.18E-08mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(1539-57-7)
• EPA Substance Registry System: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(1539-57-7)

Safety Data

• Hazardous Substances Data: 1539-57-7(Hazardous Substances Data)

Usage

General Description

1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is a chemical compound with potential application in various fields such as pharmaceuticals, agrochemicals, and materials science. It is a diester of a pyridine dicarboxylic acid that contains a benzyl group, and has two methyl substituents on the pyridine ring. 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester has been studied for its potential as an antioxidant, an anti-inflammatory agent, and as a possible treatment for neurodegenerative diseases such as Alzheimer's. Its unique structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C20H25NO4/c1-5-24-19(22)17-13(3)21-14(4)18(20(23)25-6-2)16(17)12-15-10-8-7-9-11-15/h7-11,16,21H,5-6,12H2,1-4H3

Upstream product

• 122-78-1 phenylacetaldehyde 
• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 626-34-6 ethyl aminocrotonate 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 140429-21-6 N-(1-chloro-2-phenylethyl)pyridinium chloride 
• 36873-30-0 2-benzyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 

Downstream Products

• 1149-24-2 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 65-85-0 benzoic acid 
• 94577-35-2 Diethyl 2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylate 
• 16035-87-3 N-(p-nitrobenzyl)-p-anisidine 
• 1834-74-8 (1,2-diphenyl-ethyl)-(4-methoxy-phenyl)amine 
• 436087-20-6 N-(1-(furan-2-yl)-2-phenylethyl)-4-methoxyaniline 
• 56888-48-3 5-benzylbenzene-1,2,4-tricarbonitrile 
• 23450-31-9 4-benzylbenzonitrile 
• 67468-65-9 4-benzylbenzaldehyde 
• 18908-74-2 ethyl 4-benzylbenzoate 
• 831-81-2 4-chlorophenyl(phenyl)methane 

Relevant articles and documents

Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis

An enantioselective addition reaction of various alkyl groups to unactivated internal alkenes under Cu catalysis has been developed. The reaction uses amide-linked aminoquinoline as the directing group, 4-alkyl Hantzsch esters as the donor of alkyl radicals, and rarely used biaryl diphosphine oxide as a chiral ligand. β-lactams featuring two contiguous stereocenters at Cβ and the β substituent can be obtained in good yield with excellent enantioselectivity. Mechanistic studies indicate that a nucleophilic addition of the alkyl radical to CuII-coordinated alkene is the enantio-determining step.

USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.

Novel syntheses of heterocycles with N-(1-haloalkyl)azinium halides. Part 2. Preparation of N-unsubstituted 1,4-dihydropyridines

N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and aldehydes, readily react with enaminocarbonyl derivatives to yield 1,4-dihydropyridines under mild and neutral conditions.