150674-62-7

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 301832-52-0 (S)-N-(1-hydroxy-3-buten-2-yl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 24458-20-6 methyl (2S)-4-(methylsulfanyl)-2-[[(4-methylphenyl)sulfonyl]amino]butanoate 
• 139696-34-7 (2S)-N-(4-toluenesulfonyl)-2-amino-4-methylsulfanyl-butanol 
• 150674-61-6 ((S)-1-Methoxymethoxymethyl-allyl)-carbamic acid benzyl ester 

Downstream Products

• 150674-63-8 N-But-2-ynyl-N-((S)-1-methoxymethoxymethyl-allyl)-4-methyl-benzenesulfonamide 
• 188569-93-9 [S-(E)]-N-[1-(methoxy)methoxy-3-buten-2-yl]-4-methyl-N-[3-methyl-4-(phenylsulfanyl)-2-butenyl]benzenesulfonamide 
• 150674-64-9 (1S,3aS,4S,6aS)-1-(Methoxymethoxymethyl)-4-methyl-2-(toluene-4-sulfonyl)hexahydrocyclopentapyrrol-5-one 
• 150674-66-1 (2S,3R,4R)-4-Acetyl-3-<(methoxycarbonyl)methyl>-2-(methoxymethoxymethyl)-1-(toluene-4-sulfonyl)pyrrolidine 
• 150674-65-0 (3S,3aS,6aS)-5-<(Trimethylsilyl)oxy>-3-(methoxymethoxymethyl)-6-methyl-2-(toluene-4-sulfonyl)-1,2,3,3a,4,6a-hexahydrocyclopentapyrrole 
• 188569-94-0 [2S-(2α,3β,4β)]-[2-(methoxymethoxy)methyl-4-(1-methylethenyl)-1-(4-methylphenyl)sulfonyl-3-(phenylsulfanyl)methyl]pyrrolidine 
• 188569-97-3 methyl [2S-(2α,3β,4β)]-[2-(methoxymethoxy)methyl-4-(1-methylethenyl)-1-[(4-methylphenyl)sulfonyl]-α-phenylsulfonyl]-3-pyrrolidineacetate 
• 188569-96-2 [2S-(2α,3β,4β)]-[2-(methoxymethoxy)methyl-4-(1-methylethenyl)-1-(4-methylphenyl)sulfonyl-3-(phenylsulfonyl)methyl]pyrrolidine 
• 150674-69-4 methyl [2S-(2α,3β,4β)]-[2-(methoxycarbonyl)-4-(1-methylethenyl)-1-(4-methylphenyl)sulfonyl]-3-pyrrolidineacetate 
• 150674-67-2 methyl [2S-(2α,3β,4β)]-[2-(methoxymethoxy)methyl-4-(1-methylethenyl)-1-(4-methylphenyl)sulfonyl]-3-pyrrolidineacetate 
• 150674-68-3 (2S,3S,4S)-4-Isopropenyl-3-methoxycarbonylmethyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid 
• 301832-55-3 (2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid 
• 158839-37-3 methyl [2S-(2α,3β,4β)]-[2-(hydroxymethyl)-4-(1-methylethenyl)-1-(4-methylphenyl)sulfonyl]-3-pyrrolidineacetate 

Relevant academic research and scientific papers

Radical cyclization in heterocycle synthesis. Part 10: A concise synthesis of (-)-kainic acid via sulfanyl radical addition-cyclization-elimination reaction

Sulfanyl radical addition-cyclization-elimination of diallylamines in the presence of thiophenol and AIBN gave the 2,3,4-trisubstituted pyrrolidine in high yield. This reaction was extended to a radical cyclization using a catalytic amount of thiophenol. A successful application was demonstrated by the asymmetric synthesis of (-)-kainic acid. (C) 2000 Elsevier Science Ltd.

A Total Synthesis of (-)-α-Kainic Acid By the Pauson-Khand Reaction

A total synthetic route to (-)-α-kainic acid has been developed based on the Pauson-Khand reaction as a key reaction for the construction of the bicyclo ring system.