150878-37-8

Basic information

• Product Name: 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one
• Synonyms: 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one
• CAS NO: 150878-37-8
• Molecular Weight: 340.809
• Mol File: 150878-37-8.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one(150878-37-8)
• EPA Substance Registry System: 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one(150878-37-8)

Safety Data

• Hazardous Substances Data: 150878-37-8(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 150878-36-7 6-chloro-4-cyclopropylquinazolin-2(1H)-one 
• 5922-60-1 2-amino-5-chlorobenzonitrile 

Downstream Products

• 157195-63-6 6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyridin-3-ylethynyl-3,4-dihydro-1H-quinazolin-2-one 
• 157195-64-7 6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyridin-4-ylethynyl-3,4-dihydro-1H-quinazolin-2-one 
• 157195-65-8 6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyrazin-2-ylethynyl-3,4-dihydro-1H-quinazolin-2-one 
• 157195-66-9 6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyrimidin-5-ylethynyl-3,4-dihydro-1H-quinazolin-2-one 
• 1026507-71-0 6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-3-methyl-4-pyridin-2-ylethynyl-3,4-dihydro-1H-quinazolin-2-one 
• 153800-06-7 6-chloro-4-cyclopropyl-3,4-dihydro-1-(4-methoxybenzyl)-4-<2-(2-pyridyl)ethyn-1-yl>quinazolin-2(1H)-one 
• 150878-82-3 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-4-(4-methoxybutynyl)-3-(2-methoxyethyl)-3,4-dihydroquinazolin-2(1H)-one 
• 150878-38-9 6-chloro-4-cyclopropyl-3,4-dihydro-1-(4-methoxybenzyl)-4-propylquinazolin-2(1H)-one 
• 150878-67-4 3,4-dihydro-1-(4-methoxybenzyl)-4-cyclopropyl-4-(2-butyn-1-yl)-6-chloroquinazolin-2(1H)one 
• 153800-14-7 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one 
• 150878-75-4 (+/-)-6-Chloro-4-cyclopropyl-3,4-dihydro-1-(4-methoxybenzyl)-4-n-butylquinazolin-2(1H)-one 

Relevant articles and documents

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

As part of an ongoing effort to prepare novel non-nucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT), a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin- 2(1H)-ones 4aa-1 has been prepared

Chiral resolution process

A chiral resolution process is described for the purification of a substituted chiral quinazoline, by salt formation with a resolving agent, followed by crystallization.

Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BCl3/GaCl3-induced Condensation of Anilines with Nitriles (Sugasawa Reaction)

The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

New quinazolines as inhibitors of HIV reverse transcriptase

Compounds having a quinazolin-2-one nucleus with a substituted alkynyl or substituted alkenyl at the 4-position are described. These compounds are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or