153800-14-7

Basic information

• Product Name: 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one
• Synonyms: 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one
• CAS NO: 153800-14-7
• Molecular Weight: 366.847
• Mol File: 153800-14-7.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one(153800-14-7)
• EPA Substance Registry System: 6-chloro-4-cyclopropyl-3,4-dihydro-4-ethynyl-1-(4-methoxybenzyl)quinazolin-2(1H)-one(153800-14-7)

Safety Data

• Hazardous Substances Data: 153800-14-7(Hazardous Substances Data)

Upstream product

• 150878-37-8 6-chloro-4-cyclopropyl-1-(4-methoxybenzyl)-quinazolin-2(1H)-one 
• 1066-54-2 trimethylsilylacetylene 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 824-94-2 p-methoxybenzyl chloride 
• 150878-36-7 6-chloro-4-cyclopropylquinazolin-2(1H)-one 

Relevant articles and documents

Chiral resolution process

A chiral resolution process is described for the purification of a substituted chiral quinazoline, by salt formation with a resolving agent, followed by crystallization.

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

As part of an ongoing effort to prepare novel non-nucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT), a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin- 2(1H)-ones 4aa-1 has been prepared