15088-73-0

Upstream product

• 6279-44-3 4-methoxythiobenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 21132-27-4 2-(4-methoxyphenyl)-4-phenyl-1,3-dithiol-1-ium-5-olate 
• 67-56-1 methanol 

Downstream Products

• 58600-95-6 4-methylphenyl 4-methoxybenzoate 
• 15089-03-9 4-methoxy-N'-phenylbenzohydrazide 
• 7429-03-0 potassium 4-methoxybenzenecarbothioate 
• 121623-69-6 4-methoxy-thiobenzoic acid S-(4-methoxy-trityl ester) 

Relevant academic research and scientific papers

Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4-(N,N-Dimethylamino)pyridine Catalysis

A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.

The rapid and efficient synthesis of disulfides from alkyl and acyl halides

Various symmetrical dialkyl and diacyl disulfides are prepared easily in high yields from the corresponding alkyl and acyl halides under mild and nonaqueous conditions using N,N'-dibutyl-N,N,N',N'-tetramethyl- ethylenediammonium tetrahydroborate (BTMETB) or N,N'-dibenzyl-N,N,N',N'- tetramethylethylenediammonium tetrahydroborate (BZTMETB) and elemental sulfur. The quaternary diammonium borohydrides were easily prepared by treatment of the corresponding quaternary diammonium chloride or bromide with alkaline solution of sodium borohydride at room temperature.

A facile method for the synthesis of diacyl disulfides

A facile method for the synthesis of diacyl disulfides is reported. Sulfur is reduced with samarium diiodide at room temperature to give samarium disulfides, which react with acyl chlorides in the presence of HMPA to afford the corresponding diacyl disulfides in high yields.

A convenient method for the synthesis of diacyl disulfides

A simple and general method for the synthesis of diacyl disulfides is reported. Sulfur is allowed to react with sodium hydroxide to give sodium disulfide at 65°C under PTC, which can react with acyl halides to afford diacyl disulfides in good to excellent isolated yields. The effects of solvents and phase transfer catalysts are discussed.

Neue Reaktionen mesoionischer 1,3-Dithiolone mit Singulett- und Triplett-Sauerstoff

Photochemically generated singlet oxygen combines with the 2,5-diaryl-1,3-dithiolylium-4-olates 1a, b in the presence of methanol to produce methyl phenylglyoxylate (6) and the disulfides 4a, b as a result of a fragmentation of the primarily formed cycloadducts of type 2.Whereas 1a, b show no reactivity towards triplet oxygen, the mesoionic 1,3-dithiolone 1c reacts with triplet oxygen at room temperature with formation of a 2,5,7-trithiabicycloheptanone derivative 10, whose structure is established by an X-ray crystal structure analysis.