150966-63-5

Upstream product

• 199177-32-7 (+/-)-2-hydroxy-β-cyclogeraniol 
• 17773-75-0 2-carbethoxy-1,1,3-trimethyl-1,3-butadiene 
• 144066-83-1 Acetic acid 5-chloro-5-cyano-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 52385-60-1 (3-methyl-2-methylethenyl)-2-buten-1-ol 
• 99978-27-5 2-(α-hydroxy-isopropyl)-3-methyl-crotonic acid ethyl ester 
• 35044-52-1 ethyl 2-acetyl-3-methylbut-2-enoate 
• 209069-55-6 5-(tert-Butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-1-enecarbaldehyde 
• 37715-31-4 (E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl acetate 
• 150966-81-7 6,6,8-trimethyl-1,4-dioxaspiro[4.5]decan-7-one hydrazone 
• 150966-58-8 5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene 
• 14782-52-6 ethylene glycole monoacetal of 2,2-dimethylcyclohexane-1,3-dione 
• 141665-47-6 5,5-(ethylenedioxy)-2,6,6-trimethyl-1-cyclohexenecarboxaldehyde 
• 114198-58-2 3,3-(ethylenedioxy)-2,2,6-trimethyl-1-cyclohexanone 
• 562-13-0 2,2-dimethyl-1,3-cyclohexanedione 

Downstream Products

• 150966-64-6 2-(tert-butyldimethylsiloxymethyl)-4-(2,4,6-triisoporpyl-benzenesulfonyl-hydrazono)-1,3,3-trimethyl-cyclohex-1-ene 
• 595568-62-0 5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienecarbaldehyde 
• 595568-54-0 2-(tert-butyldimethylsiloxymethyl)-4-hydroxymethyl-1,3,3-trimethyl-cyclohexa-1,4-diene 
• 595568-56-2 (4S)-2-(tert-butyldimethylsiloxymethyl)-4-hydroxy-4-(hydroxymethyl)-1,3,3-trimethyl-cyclohex-1-ene 
• 595568-60-8 (5S)-3-(tert-butyldimethylsiloxymethyl)-5-hydroxy-5-benzoyloxymethyl-2,4,4-trimethyl-cyclohex-2-en-1-one 
• 595568-59-5 (4S)-2-(tert-butyldimethylsiloxymethyl)-4,6-dihydroxy-4-benzoyloxymethyl-1,3,3-trimethyl-cyclohex-1-ene 
• 595568-53-9 (4S,5R)-2-(tert-butyldimethylsiloxymethyl)-4,6-dihydroxy-4-benzoyloxymethyl-1,3,3-trimethyl-cyclohex-1-ene 

Relevant academic research and scientific papers

A novel approach to the Taxol A-ring synthetic equivalents

A novel short approach to the A-ring synthetic equivalents of Taxol was described. Oxabicyclic ketone 3 served as a versatile template for selective functionalization leading to oxabicyclic vinylic ether 6 in two steps, which was hydrolyzed under mild aci

A concise enantioselective synthesis of a fully oxygen substituted ring A taxol precursor

A concise synthesis of the oxygen substituted ring A compound 2 found in Taxol 1a and Taxotere 1b starting from 2,2-dimethylcyclohexane-1,3-dione and proceeding via the key intermediates 8 and 11, is described. The absolute configuration of 2 was established from an X-ray crystal structure determination of a 4-bromophenylbenzoate derivative, viz. 15.

Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel

We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

Construction of A and C ring intermediates for taxol by using (3+2)-cycloaddition of nitrile oxide

Syntheses of the A-ring and the chiral C-ring model of taxol by using the intramolecular nitrile oxide cycloaddition and its diastereoselectivity based on MM2 transition state model are described.

Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system

A method for the formation of Taxol's ABC ring system has been developed. General methods for the synthesis of versatile synthons for Taxol's A ring (8) and C ring (55) are presented. A model study using a simplified C ring synthon (17) confirmed the viability of the sequential Shapiro-McMurry strategy for formation of Taxol's B ring. Careful exploration of the chemistry of various A-B ring conjugates allowed the development of a successful method for formation of the B ring in a more functionalized system.