15103-39-6

Upstream product

• 41317-10-6 2-nitroso-5-dimethylaminophenol hydrochloride 
• 140648-37-9 4-(4-Dimethylamino-2-hydroxy-phenylazo)-benzenesulfonamide 
• 446-36-6 5-fluoro-2-nitrophenol 
• 14703-83-4 5-(dimethylamino)-2-nitrophenol 
• 99-07-0 3-Dimethylaminophenol 
• 7647-01-0 hydrogenchloride 
• 16761-04-9 5-(dimethylamino)-2-nitrosophenol 

Downstream Products

• 140413-15-6 7-Dimethylamino-10-methyl-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 14703-85-6 2-amino-5-(dimethylamino)phenol dihydrochloride 
• 105074-39-3 7-Dimethylamino-3-styryl-1,4-benzoxazin-2-one 
• 105074-49-5 4-{(1E)-2-(7-(dimethylamino)-2-oxo-2H-benzo-[b][1,4]oxazin-3-yl)vinyl}benzaldehyde 
• 105074-40-6 7-dimethylamino-3-(p-(dimethylamino)styryl)-2H-1,4-benzoxazin-2-one 
• 105074-41-7 7-dimethylamino-3-(p-nitrostyryl)-2H-1,4-benzoxazin-2-one 
• 105074-42-8 7-Dimethylamino-3-(3-nitrostyryl)-1,4-benzoxazin-2-one 
• 105074-45-1 7-Dimethylamino-3-(3-benzyloxystyryl)-1,4-benzoxazin-2-one 
• 105074-46-2 7-Dimethylamino-3-(3-acetoxy-4-nitrostyryl)-1,4-benzoxazin-2-one 
• 92510-34-4 7-dimethylamino-3-phenyl-2H-1,4-benzoxazin-2-one 
• 92510-35-5 3-Benzyl-7-dimethylamino-1,4-benzoxazin-2-one 

Relevant academic research and scientific papers

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

Lysozyme-targeted ratiometric fluorescent probe for SO2 in living cells

Sulfur dioxide (SO2) as a common environmental pollutant, participates in a variety of physiology and pathological processes in vivo. Lysosomes are considered to be cleaners of living cells and play a vital role in the process of metabolism. Exposure to excess SO2 will result in the increase risk of lysosomal dysfunction and induce multiple diseases. Herein a smart fluorescent probe LYSO-SO2 is developed, which achieved the ratio (F561 nm/F634 nm) identification of SO2 in vitro. LYSO-SO2 showed high sensitivity (detection limit 15.8 nM), rapidly response (within 5 s), and excellent selectivity. Additionally, this probe LYSO-SO2 has been successfully applied to the ratio monitoring SO2 in lysosomes which may provide an effective quantitative method for studying the physiological and pathological functions of SO2 in living cells.

A fluorescent probe for bisulfite ions: its application to two-photon tissue imaging

A benzoxazinone based fluorescent probe for the specific and efficient detection of bisulfite ions in aqueous medium is described. The probe formed a bisulfite/sulphite adduct with an associated turn-on fluorescence response in the red wavelength region. No interference was observed in the detection process from all possible competing anions and molecules, including cyanide ion, cysteine, homocysteine and glutathione. In addition, the probe showed a fast response time, low detection limit, and cell membrane permeability. Furthermore, the probe was two-photon excitable, enabling imaging of endogenous bisulfite ions in HeLa cells as well as in deep tissues from different organs of mouse.

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.

LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES

Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodiaxazole nucleus, coumarin nucleus or aza coumarin nucleus.

POLAROGRAPHIC AND CYCLIC VOLTAMMETRIC BEHAVIOUR OF SOME AZO COMPOUNDS DERIVED FROM SULFONAMIDE IN DMF-AQUEOUS SOLUTIONS

The polarographic and cyclic voltammetric behaviour of (2-hydroxyphenylazo)-4-benzenesulfonamide and some of its derivatives have been studied in Britton-Robinson buffer series containing 30 vol.percent of DMF.Over the entire pH range (2-12), the reduction pathway occurs through an irreversible 4-electron step corresponding to the reduction of N=N center to the amine stage.The voltammograms recorded in acidic and alkaline solution at different scan rates exhibit one or two cathodic peaks depending on the substituent and the pH of the medium.The electrode reaction mechanism was suggested, also the kinetic parameters were calculated.

Tetrachloroferrates of basic dyes

Basic dyes of the formula where Chra is a dye cation are useful for dyeing acrylonitrile polymers or acid-modified polyesters.

Synthesis and Fluorescence Analysis of 3-Substituted 7-Dialkylamino-2H-1,4-benzoxazin-2-ones

New benzoxazinone type dyes have been synthesized by the reaction of α-keto esters on 2-amino-5(dialkylamino)phenols The obtained 7-dialkylamino-2H-1,4-benzoxazin-2-ones show a strong fluorescence and a large Stokes shift, reaching 183 nm.An effect of 15

Synthesis and Properties of Some 7-Dimethylamino-1,4-benzoxazin-2-ones

The synthesis of the 7-dimethylamino-1,4-benzoxazin-2-ones (5), fluorescent dyes, by condensing α-ketoacids with 2-amino-5-dimethylaminophenol is described.When the 3-substituent is a methyl group, these compounds can be further condensed with aromatic aldehydes to provide the styryl dyes (6).These products are easily opened by hydrochloric acid in ethanolic solution to afford the corresponding benzalketoacid ethyl esters (7).