15116-34-4

Usage

Physical properties

white to light yellow crystalline powder

Solubility

insoluble in water

Stability

stable under normal conditions

Uses

primarily used as an intermediate in the production of pharmaceuticals and fragrances

Biological activity

potential biological activity, making it of interest in the pharmaceutical industry

Research and development

used in research and development efforts.

InChI:InChI=1/C12H14O3/c1-12(2,11(14)15)8-10(13)9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,14,15)

Upstream product

• 594815-53-9 ethyl 2,2-dimethyl-4-oxo-4-phenylbutanoate 
• 83188-31-2 ethyl 2,2-dimethyl-4-phenyl-3-butynoate 
• 1483-82-5 phenylethynyl chloride 
• 14308-33-9 2,2-dimethoxy-3,3-dimethyl-5-phenyl-2,3-dihydro-furan 
• 17347-61-4 2,2-dimethylsuccinic anhydride 
• 71-43-2 benzene 
• 147643-74-1 ethyl 4-chloro-2,2-dimethyl-4-oxobutanoate 
• 7446-70-0 aluminium trichloride 
• 91735-32-9 methyl 4-chloro-3,3-dimethyl-4-oxo-butanoate 

Relevant academic research and scientific papers

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

Iridium-Catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated γ-Lactams: Scope and Mechanistic Studies

An efficient asymmetric hydrogenation of β,γ-unsaturated γ-lactams using an iridium-phosphoramidite complex is reported. The chiral γ-lactams were obtained in excellent yields and enantioselectivities (up to 99% yield and 99% ee). The mechanistic studies

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors from TE85 osteosarcoma cells but > 1 μM binding affinity to the progesterone receptors from T47D and ZR75 human breast carcinpma cells.Structure-activity relationships were developed for a set of these compounds, and a representative analog 1-(3,4-dichlorobenzoyl)-3-phenyl-1,4,5,6-tetrahydropyridazine (1i, RWJ 25333) was chosen for further evaluation.RWJ 25333 stimulated the in vitro proliferation of human osteoblast-like cells but not human breast cells.

CHLOROACETYLENES AS MICHAEL ACCEPTORS. II. DIRECT ETHYNYLATION AND VINYLATION OF TERTIARY ENOLATES.

The reaction of ClCCCl, PhCCCl and PhSCCCl with a variety of tertiary enolates leads in 43-90percent yields to α-chloroethynyl, α-phenylethynyl and α-thiophenylethynyl derivatives.The -CCCl group is smoothly converted to -CCH using copper p