15116-34-4

Basic information

• Product Name: 2,2-DIMETHYL-4-OXO-4-PHENYLBUTYRIC ACID
• Synonyms: 2,2-DIMETHYL-4-OXO-4-PHENYLBUTYRIC ACID;2,2-Dimethyl-4-oxo-4-phenylbutanoic acid
• CAS NO: 15116-34-4
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 15116-34-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 364.6°C at 760 mmHg
• Flash Point: 188.5°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 5.91E-06mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 2,2-DIMETHYL-4-OXO-4-PHENYLBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-4-OXO-4-PHENYLBUTYRIC ACID(15116-34-4)
• EPA Substance Registry System: 2,2-DIMETHYL-4-OXO-4-PHENYLBUTYRIC ACID(15116-34-4)

Safety Data

• Hazardous Substances Data: 15116-34-4(Hazardous Substances Data)

Usage

Physical properties

white to light yellow crystalline powder

Solubility

insoluble in water

Stability

stable under normal conditions

Uses

primarily used as an intermediate in the production of pharmaceuticals and fragrances

Biological activity

potential biological activity, making it of interest in the pharmaceutical industry

Research and development

used in research and development efforts.

InChI:InChI=1/C12H14O3/c1-12(2,11(14)15)8-10(13)9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,14,15)

Upstream product

• 17347-61-4 2,2-dimethylsuccinic anhydride 
• 71-43-2 benzene 
• 14308-33-9 2,2-dimethoxy-3,3-dimethyl-5-phenyl-2,3-dihydro-furan 
• 147643-74-1 ethyl 4-chloro-2,2-dimethyl-4-oxobutanoate 
• 1483-82-5 phenylethynyl chloride 
• 7446-70-0 aluminium trichloride 
• 91735-32-9 methyl 4-chloro-3,3-dimethyl-4-oxo-butanoate 
• 83188-31-2 ethyl 2,2-dimethyl-4-phenyl-3-butynoate 
• 594815-53-9 ethyl 2,2-dimethyl-4-oxo-4-phenylbutanoate 

Downstream Products

• 34440-74-9 4-Hydroxy-2.2-dimethyl-4-phenylbuttersaeure 

Relevant articles and documents

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors from TE85 osteosarcoma cells but > 1 μM binding affinity to the progesterone receptors from T47D and ZR75 human breast carcinpma cells.Structure-activity relationships were developed for a set of these compounds, and a representative analog 1-(3,4-dichlorobenzoyl)-3-phenyl-1,4,5,6-tetrahydropyridazine (1i, RWJ 25333) was chosen for further evaluation.RWJ 25333 stimulated the in vitro proliferation of human osteoblast-like cells but not human breast cells.

Anorexiant activity in rat of acids derived from aryl cycloalkyl ketones

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