15118-70-4

Usage

InChI:InChI=1/C12H13NO5/c1-2-18-12(15)8-7-11(14)9-3-5-10(6-4-9)13(16)17/h3-6H,2,7-8H2,1H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 55949-67-2 1-morpholino-1-(4-nitrophenyl)ethene 
• 555-16-8 4-nitrobenzaldehdye 
• 140-88-5 ethyl acrylate 
• 42216-96-6 triethyl orthoacrylate 
• 122-04-3 4-nitro-benzoyl chloride 
• 6414-69-3 ethyl 3-iodopropanoate 
• 14308-34-0 2,2-diethoxy-5-(4-nitro-phenyl)-2,3-dihydro-furan 

Downstream Products

• 177269-10-2 4-(4-nitrophenyl)pent-4-enal 
• 6335-44-0 ethyl 4-(4-aminophenyl)-4-oxobutyrate 

Relevant academic research and scientific papers

Tris(4-methoxylphenyl)phosphine-catalyzed C-C bond formation reaction: Mutual addition of aromatic aldehydes and ethyl acrylate

A highly efficient intermolecular mutual addition of aromatic aldehydes with ethyl acrylate was developed by using tris(4-methoxylphenyl)phosphine as the catalyst. The reaction corresponds to the construction of 1,4-dicarbonyl compound and allylic alcohol

Efficient synthesis of γ-keto esters from enamines and EDA

The reaction of enamines with ethyl diazoacetate (EDA) catalyzed by dirhodium and copper complexes provided γ-keto esters in good yields. The influences of catalyst, reaction solvent, temperature, and structure of enamines on this transformation were inve

Cu(I)-assisted carbon-carbon bond forming reactions of γ,γ-dialkoxyallylic zirconium species: A new versatile homoenolate equivalent of propionate

In the presence of CuCN, reaction of γ,γ-dialkoxyallylic zirconium species 1 with acyl chloride or allylic phosphates proceeded at the α-position of 1 to give alkanoates 3 after aqueous work-up. The ketene dialkylacetal moiety in the coupling products 2 can be used for further bond forming reaction with electrophiles such as nitrosobenzene, nitrostyrene or trichloroacetylisocyanate. (C) 2000 Elsevier Science Ltd.

ortho-halogeno substituents effect in asymmetric cyclization of 4-aryl-4-pentenals using a rhodium catalyst

Asymmetric cyclization of 4-aryl-4-pentenals by using a cationic [Rh((R)-BINAP)]ClO4 afforded (3R)-3-substituted cyclopentanones; on the other hand, the cyclization of 4-pentenals bearing ortho-halogeno phenyl groups afforded the opposite (3S)-ones.

PHARMACEUTICAL COMPOUNDS

The present invention relates to novel benzoquinazoline thymidylate synthase inhibitors, to pharmaceutical formulations containing them and to their use in medicine