15118-70-4

Basic information

• Product Name: ETHYL 4-(4-NITROPHENYL)-4-OXOBUTYRATE
• Synonyms: ETHYL 4-(4-NITROPHENYL)-4-OXOBUTYRATE
• CAS NO: 15118-70-4
• Molecular Formula: C₁₂H₁₃NO₅
• Molecular Weight: 251.24
• Mol File: 15118-70-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 396.879°C at 760 mmHg
• Flash Point: 175.347°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: ETHYL 4-(4-NITROPHENYL)-4-OXOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(4-NITROPHENYL)-4-OXOBUTYRATE(15118-70-4)
• EPA Substance Registry System: ETHYL 4-(4-NITROPHENYL)-4-OXOBUTYRATE(15118-70-4)

Safety Data

• Hazardous Substances Data: 15118-70-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO5/c1-2-18-12(15)8-7-11(14)9-3-5-10(6-4-9)13(16)17/h3-6H,2,7-8H2,1H3

Upstream product

• 42216-96-6 triethyl orthoacrylate 
• 122-04-3 4-nitro-benzoyl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 140-88-5 ethyl acrylate 
• 623-73-4 diazoacetic acid ethyl ester 
• 55949-67-2 1-morpholino-1-(4-nitrophenyl)ethene 
• 6414-69-3 ethyl 3-iodopropanoate 
• 14308-34-0 2,2-diethoxy-5-(4-nitro-phenyl)-2,3-dihydro-furan 

Downstream Products

• 6335-44-0 ethyl 4-(4-aminophenyl)-4-oxobutyrate 
• 177269-10-2 4-(4-nitrophenyl)pent-4-enal 

Relevant articles and documents

Tris(4-methoxylphenyl)phosphine-catalyzed C-C bond formation reaction: Mutual addition of aromatic aldehydes and ethyl acrylate

A highly efficient intermolecular mutual addition of aromatic aldehydes with ethyl acrylate was developed by using tris(4-methoxylphenyl)phosphine as the catalyst. The reaction corresponds to the construction of 1,4-dicarbonyl compound and allylic alcohol

Cu(I)-assisted carbon-carbon bond forming reactions of γ,γ-dialkoxyallylic zirconium species: A new versatile homoenolate equivalent of propionate

In the presence of CuCN, reaction of γ,γ-dialkoxyallylic zirconium species 1 with acyl chloride or allylic phosphates proceeded at the α-position of 1 to give alkanoates 3 after aqueous work-up. The ketene dialkylacetal moiety in the coupling products 2 can be used for further bond forming reaction with electrophiles such as nitrosobenzene, nitrostyrene or trichloroacetylisocyanate. (C) 2000 Elsevier Science Ltd.

PHARMACEUTICAL COMPOUNDS

The present invention relates to novel benzoquinazoline thymidylate synthase inhibitors, to pharmaceutical formulations containing them and to their use in medicine