1515-75-9

Usage

Uses

Used in Chemical Synthesis:
1,3-Butadiene-1-carboxylic acid methyl ester is used as a key intermediate in the synthesis of various organic compounds. Its involvement in the AMBH reaction allows for the creation of new molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,3-Butadiene-1-carboxylic acid methyl ester may be used as a building block for the development of new drugs. The AMBH reaction it undergoes can lead to the formation of novel bioactive molecules with potential therapeutic properties.
Used in Material Science:
1,3-Butadiene-1-carboxylic acid methyl ester can be utilized in the development of new materials with specific properties. The compounds derived from the AMBH reaction may have unique characteristics that can be applied in various material science applications, such as polymers, coatings, or adhesives.
Used in Research and Development:
1,3-Butadiene-1-carboxylic acid methyl ester is used as a research compound for exploring new reaction pathways and understanding the mechanisms of the AMBH reaction. This knowledge can be applied to develop more efficient and environmentally friendly synthetic methods in the future.

Synthesis Reference(s)

Journal of the American Chemical Society, 94, p. 4395, 1972 DOI: 10.1021/ja00767a088Synthesis, p. 534, 1988 DOI: 10.1055/s-1988-27626

InChI:InChI=1/C6H8O2/c1-3-4-5-6(7)8-2/h3-5H,1H2,2H3/b5-4+

Upstream product

• 67-56-1 methanol 
• 626-99-3 1,3-butadiene-1-carboxylic acid 
• 120990-32-1 (3E)-2-acetoxypent-3-enoate 
• 141-82-2 malonic acid 
• 107-02-8 acrolein 
• 74-88-4 methyl iodide 
• 74-85-1 ethene 
• 89123-62-6 Methyl 3-bromopropenoate 
• 38330-80-2 monomethyl monopotassium malonate 

Downstream Products

• 91396-02-0 2-(4-chloro-phenyl)-3,6-dihydro-2H-[1,2]oxazine-6-carboxylic acid methyl ester 
• 412283-57-9 3,6-Dihydro-<1.2>oxazin-6-carbonsaeure-methylester 
• 96293-26-4 2-<5-(1-carbomethoxypent-2-enyl)>cyclohexanone 
• 79236-16-1 1-methyl-2-(methoxycarbonyl)-3-cyclohexen-1-carboxaldehyde 
• 111945-72-3 <1R*,2R*>-1-Acetyl-2-(methoxycarbonyl)-3-cyclohexen-1-yl p-nitrobenzoate 
• 111945-72-3 <1R*,2S*>-1-Acetyl-2-(methoxycarbonyl)-3-cyclohexen-1-yl p-nitrobenzoate 
• 124939-60-2 (propene-2 oate de methyle) yl-4 cyclohexene trans 
• 86370-81-2 methyl 2,6-cyclooctadienecarboxylate 
• 4949-20-6 2,4-pentadien-1-ol 
• 1174935-82-0 C₂₄H₂₃BF₂N₂O₂ 
• 1174935-83-1 C₃₀H₂₉BF₂N₂O₄ 
• 1174935-76-2 C₂₄H₂₃BF₂N₂O₂ 
• 1174935-77-3 C₃₀H₂₉BF₂N₂O₄ 
• 32692-31-2 6,11-dioxo-1,4,6,11-tetrahydro-pyridazino[1,2-b]phthalazine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Preparation of cilazapril intermediates

The present application relates to cilazapril intermediates and processes for the preparation of cilazapril intermediates, including (S)-6,11-dioxo-1,2,3,4,6,11-hexahydro-pyridazino[1,2-b]naphthalazine-1-carboxylic acid and its salts.

Low pressure vinylation of aryl and vinyl halides via Heck-Mizoroki reactions using ethylene

Aryl bromides and iodides in the presence of catalytic amounts of a palladacycle derived from acetophenone oxime and 2 equiv of potassium acetate react with ethylene under ambient pressure (15-30 psi) to give the corresponding vinylarenes. The reactions work with both electron-deficient and electron-rich aryl compounds and tolerate wide variety of common functional groups. Vinyl bromides lead to 1,3-dienes in moderate yields.

Silyl Nitronates in Organic Synthesis. Routes to Heterocycles and Cyclopentanoids. Synthesis of Allethrolone and Calythrone. Acylation and Cyanohydroxylation of Double Bonds. An Exploratory Study

Silyl nitronates are versatile reagents for the preparation of heterocycles by dipolar addition to double bonds.The intermediate isoxazolidines can be transformed to 2-isoxazolines, isoxazoles, furans, dihydrofuranones, pyrazoles, pyridazines and pyridazones.Reduction of 2-isoxazolines with Ti3+ leads to hydroxylated 1,4-diketones, which subsequently can be cyclized to cyclopentenones.Routes to calythrone, rethrolones, prostanoids and a number of naturally occurring dihydrofuranones are devised, as well as synthetic procedures for acylation, preparation of endiones, hydroxyacylation, cyanation and hydroxycyanation of double bonds.