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1516895-53-6

SEP-0372814 is a pyrido[2,3-d]pyrimidine-based chemical compound that has been identified as a potent and selective inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6). These enzymes play a crucial role in cell cycle regulation, and by targeting them, SEP-0372814 exhibits significant anti-proliferative effects in preclinical studies. Its potential as a therapeutic agent is further supported by its good oral bioavailability and favorable pharmacokinetic properties. Further research and clinical trials are necessary to assess the efficacy and safety of SEP-0372814 for cancer treatment.

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  • 1516895-53-6 Structure

  • Basic information

    1. Product Name: SEP-0372814
    2. Synonyms: SEP-0372814;rel-2-[(1R,2R)-2-(5,8-Dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl]-3-methylimidazo[2,1-f][1,6]naphthyridine
    3. CAS NO:1516895-53-6
    4. Molecular Formula: C21H19N7
    5. Molecular Weight: 369.42246
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1516895-53-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.52±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 5.38±0.50(Predicted)
    10. CAS DataBase Reference: SEP-0372814(CAS DataBase Reference)
    11. NIST Chemistry Reference: SEP-0372814(1516895-53-6)
    12. EPA Substance Registry System: SEP-0372814(1516895-53-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1516895-53-6(Hazardous Substances Data)

1516895-53-6 Usage

Uses

Used in Pharmaceutical Industry:
SEP-0372814 is used as a potential therapeutic agent for the treatment of various cancers due to its ability to inhibit CDK4 and CDK6, key regulators of cell division. Its anti-proliferative effects have shown promise in preclinical studies, making it a candidate for further research and clinical trials.
Used in Cancer Research:
In cancer research, SEP-0372814 is used as a tool to study the role of CDK4 and CDK6 in cell cycle regulation and their potential as targets for cancer therapy. Its potent and selective inhibition of these enzymes provides valuable insights into the development of novel cancer treatments.
Used in Drug Development:
SEP-0372814 is used in drug development as a lead compound for the design and synthesis of new molecules with improved potency, selectivity, and pharmacokinetic properties. Its good oral bioavailability and favorable pharmacokinetics make it an attractive starting point for the development of next-generation CDK inhibitors for cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 1516895-53-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,1,6,8,9 and 5 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1516895-53:
(9*1)+(8*5)+(7*1)+(6*6)+(5*8)+(4*9)+(3*5)+(2*5)+(1*3)=196
196 % 10 = 6
So 1516895-53-6 is a valid CAS Registry Number.

1516895-53-6Relevant articles and documents

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

-

, (2014/01/09)

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

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