23616-32-2

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-1,6-NAPHTHYRIDINE is used as a building block for the synthesis of pharmaceuticals, leveraging its unique structure and reactivity to contribute to the development of new drugs. Its presence in the molecular composition of various compounds can enhance their therapeutic properties, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CHLORO-1,6-NAPHTHYRIDINE serves as a key intermediate in the synthesis of agrochemicals. Its role in creating effective crop protection products is vital, as it can be incorporated into molecules that target pests and diseases, thereby improving agricultural yields and sustainability.
Used in Organic Synthesis:
5-CHLORO-1,6-NAPHTHYRIDINE is utilized as a valuable intermediate in organic synthesis processes. Its unique chloro group attachment to the naphthyridine ring allows for various chemical reactions, facilitating the creation of a wide range of organic compounds for different applications across various industries.

InChI:InChI=1/C8H5ClN2/c9-8-6-2-1-4-10-7(6)3-5-11-8/h1-5H

Upstream product

• 23616-31-1 1,6-naphthyridine-5(6H)-one 
• 106837-37-0 2-(2-hydroxy-ethyl)-nicotinic acid amide 
• 5860-72-0 7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one 
• 65719-09-7 methyl 2-methylnicotinate 
• 97308-56-0 2-(2,2-dimethoxy-ethyl)-nicotinamide 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 
• 97308-49-1 2-trimethylsilylethynyl-3-pyridinecarbonitrile 

Downstream Products

• 1516895-53-6 trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine 
• 1516896-09-5 3-methyl-2-((1S,2S)-2-(quinolin-2-yl)cyclopropyl)-3H-imidazo[4,5-f]quinoline 
• 1516896-06-2 C₂₁H₁₉N₇ 
• 23616-35-5 2,5-dichloro-1,6-naphthyridine 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 253-72-5 1,6-naphthyridine 
• 13623-84-2 1,2,3,4-tetrahydro-1,6-naphthyridine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

Octahydropyrrolo[3,4-c]pyrrole derivative and application method and application thereof

The invention relates to an octahydropyrrolo[3,4-c]pyrrole derivative and an application method and application thereof. The compound and a pharmaceutical composition containing the compound are usedfor antagonizing orexin receptors. The invention also re

Wnt SIGNALING INHIBITOR, COMPOSITION, AND COMPOUND AS USE THEREFOR

PROBLEM TO BE SOLVED: To provide an inhibitor for Wnt signaling route. SOLUTION: The present invention provides a compound represented by formula I, and a composition comprising the compound (X1-X8 independently represent CR4 or N; Y1 is H or C (R4)3; Y2 and Y3 independently represent H, halogen or C (R3)3; R1 and R2 independently represent H, halogen, C1-6 alkyl, quinolinyl or the like; R3s independently represent H, halogen, cyano, C1-6 alkyl or the like; R4s independently represent H, halogen, cyano, C1-6 alkoxy or the like). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Inhibiting WNT signal conduction of compound, composition and use thereof (by machine translation)

The invention relates to a having the general formula (1) compounds and compositions thereof, and the use of the compound or composition thereof to inhibit WNT signal transmission method. The compounds of this invention and its composition can effectively inhibit the secretion of WNT protein, inhibit WNT signal conduction, so the WNT-mediated disease with a very good therapeutic effect. . (by machine translation)

TUMOR BIOMARKERS AND USE THEREOF

Disclosed herein are biomarkers related to WNT signal transduction pathway, as well as methods and kits comprising the same. Further, the present disclosure relates to the use of the biomarkers in patient selection, companion diagnostics, and treatment of cancer.

Compound as WNT Signaling Inhibitor, Composition, and Use Thereof

The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the compound and the method of inhibiting the WNT signal transduction pathways.

COMPOUNDS FOR TREATMENT OF CANCER

The present invention relates to compounds as inhibitor of WNT signal transduction pathway, as well as a composition comprising the same. Further, the present invention relates to the use of the compounds in the treatment of cancer.

COMPOUNDS FOR TREATMENT OF FIBROSIS DISEASES

The present invention relates to compounds as inhibitor of WNT signal transduction pathway, as well as a composition comprising the same. Further, the present invention relates to the use of the compounds in the treatment of fibrosis. Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury.

COMPOUND AS WNT SIGNALING INHIBITOR, COMPOSITION, AND USE THEREOF

The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the compound and the method of inhibiting the WNT signal transduction pathways.