151721-32-3Relevant articles and documents
Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions
Eid, Nadim,Karamé, Iyad,Andrioletti, Bruno
, p. 5016 - 5022 (2018)
Ideally, a sustainable chemical synthesis should involve the use of non-toxic solvents and reactants, easy separations and purification by energy-efficient processes. In this context, reconsidering the synthesis of widely used drugs is especially timely and should allow important benefits to be obtained in terms of environmental impact. Sulfonamides are pertinent as their synthesis generally requires the use of toxic and/or hard-to-remove solvents such as dichloromethane, DMF and DMSO. In addition, toxic and highly reactive sulfur-containing sources such as sulfonyl chloride are often involved and coupled with amines. Moreover, the latter may exhibit some toxicity and are generally difficult to purify. Herein, we disclose the unprecedented and sustainable synthesis of sulfonamides by using sodium sulfinate as a commercial and stable sulfur source and nitroarenes as the nitrogen-containing reactant. In addition, under the optimized conditions only water is used as a “green” solvent and the products are collected by simple filtration.
Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing
Liou, Yan-Cheng,Lin, Yan-An,Wang, Ke,Yang, Juan-Cheng,Jang, Yeong-Jiunn,Lin, Wenwei,Wu, Yang-Chang
, (2021/06/14)
A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy
Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils
Liang, Baihui,Huang, Junjie,Zhu, Weidong,Li, Yawen,Jiang, Lanping,Gao, Yang,Xie, Feng,Li, Yibiao,Chen, Xiuwen,Zhu, Zhongzhi
, p. 1466 - 1473 (2021/02/09)
A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.
Synthesis method of o-acylaniline sulfonamide compound
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Paragraph 0076-0082, (2020/10/30)
The invention discloses a synthesis method of a o-acylaniline sulfonamide compound. The preparation method is characterized by comprising the following steps: mixing a benzisoxazole compound as shownin a chemical formula I, a sodium sulfinate compound as shown in a chemical formula II, a metal catalyst and a solvent, and reacting to obtain the o-acylaniline sulfonamide compound as shown in a chemical formula III, in the formula, R1 is a monosubstituted or polysubstituted group on a benzene ring. The synthesis method can be used for efficiently synthesizing the o-acylaniline sulfonamide compound, has the advantages of simple synthesis steps, safety in operation, good compatibility of the synthesis method to functional groups and high atom economy, and is easy for industrial synthesis.
Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization
Zhao, Quan-Qing,Li, Man,Xue, Xiao-Song,Chen, Jia-Rong,Xiao, Wen-Jing
supporting information, p. 3861 - 3865 (2019/05/24)
A neutral nitrogen radical-mediation strategy, wherein the existing N-H moiety of substrates serves as a neutral nitrogen radical precursor to enable room-temperature intermolecular radical difunctionalization of styrenes under photoredox catalysis, is reported. The reaction shows high functional group tolerance and substrate scope with respect to both components, giving the corresponding products with generally good yields. Preliminary control experiments and DFT calculations are performed to explain the reaction mechanism.
Rhodium(iii)-catalyzed coupling of N-sulfonyl 2-aminobenzaldehydes with oxygenated allylic olefins through C-H activation
Yang, Tingting,Zhang, Tao,Yang, Shangdong,Chen, Shanshan,Li, Xingwei
, p. 4290 - 4294 (2014/06/23)
Rh(iii)-catalyzed coupling of N-sulfonyl 2-aminobenzaldehydes with oxygenated allylic olefins via C-H bond activation is described. Diarylketones were obtained through coupling of N-sulfonyl 2-aminobenzaldehydes with 7-oxabenzonorbornadienes. On the other
One-pot synthesis of 1-phenylsulfonyl-2-aroylindoles
Dhayalan, Vasudevan,Panchapakesan, Ganapathy,Mohanakrishnan, Arasambattu K.
, p. 402 - 411 (2011/11/13)
Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1- phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.Copyright Taylor & Francis Group, LLC.
Synthesis of novel nitrogen-containing ligands for the enantioselective addition of diethylzinc to aldehydes
Fonseca, Maria Hechavarria,Eibler, Ernst,Zabel, Manfred,Koenig, Burkhard
, p. 1989 - 1994 (2007/10/03)
New nitrogen-containing ligands derived from the (1R,2R)-trans-cyclohexanediamine chiral core unit have been synthesized and fully characterized. Their catalytic activity was tested in the asymmetric addition of diethylzinc to aldehydes leading to the res
