40899-90-9

Usage

Uses

Used in Pharmaceutical Research:
PSI is utilized as a potential drug candidate for various medical conditions due to its inhibitory effects on enzymes and its potential anti-inflammatory and antitumor properties.
Used in Enzyme Inhibition:
PSI is used as an enzyme inhibitor targeting tryptophan 2,3-dioxygenase, playing a role in immune modulation and the kynurenine pathway, which is significant for the development of treatments related to these biological processes.
Used in Anti-inflammatory Applications:
Given its potential anti-inflammatory properties, PSI is considered for applications aimed at reducing inflammation, which could be beneficial in treating a range of inflammatory conditions.
Used in Antitumor Applications:
PSI is employed as an antitumor agent for its potential to exhibit cytotoxic effects on various cancer cell lines, making it a candidate for cancer treatment development.
Used in Drug Development:
In the field of drug development, PSI is explored for its potential to become a therapeutic agent, particularly for conditions where its enzyme inhibition, anti-inflammatory, and antitumor properties could offer novel treatment options.
Further research is essential to understand the full pharmacological potential of PSI and to translate these findings into effective and safe therapeutic applications.

InChI:InChI=1/C21H15NO3S/c23-21(16-9-3-1-4-10-16)20-15-17-11-7-8-14-19(17)22(20)26(24,25)18-12-5-2-6-13-18/h1-15H

Upstream product

• 40899-71-6 1-benzenesulfonylindole 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 98-88-4 benzoyl chloride 
• 5344-90-1 2-Aminobenzyl alcohol 
• 151721-32-3 N-benzenesulfonyl-o-aminobenzaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 197847-57-7 N-[2-(hydroxymethyl)phenyl]benzenesulfonamide 
• 50707-35-2 2-benzoyl-2,3-dihydro-isoindol-1-one 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 1022-86-2 2-benzoylindole 

Relevant academic research and scientific papers

One-pot synthesis of 1-phenylsulfonyl-2-aroylindoles

Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1- phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.Copyright Taylor & Francis Group, LLC.

Heterocycles from ylides. Part X.Synthesis of 3-hydroxy-2,3-dihydroindoles by a domino reaction

A domino reaction between 2-N-phenylsulfonylaminobenzaldehyde (1) and sulfonium ylides (2) leads to 3-hydroxy-2,3-dihydroindoles (3) whose structure was confirmed on the basis of analytical and spectroscopic data.

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas

2-acyl indole derivatives and their use as antitumor agents

The invention relates to novel indole and heteroindole derivatives of the formula I to their tautomers, their stereoisomers, their mixtures and their salts, to their preparation and to the use of indole derivatives of the formula I as antitumor agents.

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents

A new class of simple synthetic antimitotic compounds based on 2-aroylindoles was discovered. (5-Methoxy-1H-2-indolyl)-phenylmethanone (1) as well as analogous 3-fluorophenyl- (36) and 3-methoxyphenyl (3) derivatives displayed high cytotoxicity of IC

Indole-β-nucleophilic substitution. Part 9. Nitrogen nucleophiles. Syntheses of hydroxycryptolepine, cryptolepine, and quindoline

The alkaloids hydroxycryptolepine, cryptolepine and quindoline have been synthesised utilising the intramolecular β-nucleophilic substitution of a 1- phenylsulfonyl-2-acylindole.

Synthesis of the Carbazole Alkaloid Hyellazole

Hyellazole, a new carbazole alkaloid, was synthesized via cyclisation of a 2,3-bis-vinylindole derivative.