151723-79-4

Upstream product

• 120363-13-5 tert-butyl 4-iodobenzoate 
• 134372-99-9 3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal 
• 105-53-3 diethyl malonate 

Downstream Products

• 153170-76-4 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 
• 151723-87-4 4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid 
• 153170-71-9 4-<2-(2-oxo-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid, 2,2-dimethylethyl ester 
• 153170-75-3 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester 
• 126016-78-2 N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF LY288601, A 5,6-DIHYDROPYRROLOPYRIMIDINE BASED ANTIFOLATE COMPOUND RELATED TO LY231514

An expeditious synthesis of LY288601 (2), the 5,6-dihydro analog of the pyrrolopyrimidine-based antifolate compound LY231514 (1a), is described.The synthesis proceeds in eight steps from tert-butyl 4-iodobenzoate and involves the elaboration of a 2