15184-97-1

Basic information

• Product Name: BenzeneMethanaMine, 3-chloro-N,N-diMethyl-
• Synonyms: BenzeneMethanaMine, 3-chloro-N,N-diMethyl-;3-Chloro-N,N-dimethyl-benzenemethanamine
• CAS NO: 15184-97-1
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.65128
• Mol File: 15184-97-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzeneMethanaMine, 3-chloro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanaMine, 3-chloro-N,N-diMethyl-(15184-97-1)
• EPA Substance Registry System: BenzeneMethanaMine, 3-chloro-N,N-diMethyl-(15184-97-1)

Safety Data

• Hazardous Substances Data: 15184-97-1(Hazardous Substances Data)

Usage

General Description

BenzeneMethanaMine, 3-chloro-N,N-diMethyl- is a chemical compound with the molecular formula C8H10ClN. It is also known by the name 3-Chloro-N,N-dimethylbenzylamine and is used in a variety of industrial applications, such as in the production of pharmaceuticals, pesticides, and other organic compounds. BenzeneMethanaMine, 3-chloro-N,N-diMethyl- is a colorless liquid with a strong, ammonia-like odor, and it is considered to be a hazardous substance due to its toxic and irritant properties. It is important to handle and store this chemical with caution and in accordance with safety regulations.

Upstream product

• 100-97-0 hexamethylenetetramine 
• 766-80-3 1-bromomethyl-3-chlorobenzene 
• 24167-52-0 N,N-dimethyl-3-chlorobenzamide 
• 50-00-0 formaldehyd 
• 4152-90-3 m-chlorobenzylamine 
• 587-04-2 m-Chlorobenzaldehyde 
• 67-56-1 methanol 
• 126799-85-7 3-chlorobenzylazide 
• 766-84-7 3-chloro-benzonitrile 
• 124-40-3 dimethyl amine 
• 108-41-8 1-chloro-3-methylbenzene 
• 74-88-4 methyl iodide 

Downstream Products

• 1192229-92-7 3-chlorobenzyldimethylamine borane 
• 1384216-50-5 C₁₅H₂₃BClNO₂ 
• 1384216-47-0 1-[5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N,N-dimethylmethanamine 
• 1259324-51-0 N-(tert-butoxycarbonylmethyl)-N-(3-chlorobenzyl)-N,N-dimethylammonium bromide 
• 587-04-2 m-Chlorobenzaldehyde 

Relevant articles and documents

Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application

Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.

A Novel Route to Synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen?

Developing simple and green routes to access valuable chemicals is of significance. Herein, we present a green and novel route to synthesize N,N-dimethyl arylmethylamines (DAMAs) from hexamethylenetetramine (HMTA) and aryl aldehydes in the presence of hydrogen, and a series of DAMAs can be obtained in good yields. This approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group, which has promising applications for N-containing chemicals synthesis.

Lewis Acid-Catalyzed Reductive Amination of Aldehydes and Ketones with N,N-Dimethylformamide as Dimethylamino Source, Reductant and Solvent

A practical zinc acetate dihydrate-catalyzed reductive amination of various carbonyl compounds with N,N-dimethylformamide (DMF) as dimethylamino (Me2N) source, reductant and solvent has been developed. This reaction shows broad substrate scope,