15185-51-0

Upstream product

• 75-15-0 carbon disulfide 
• 7732-18-5 water 
• 98-86-2 acetophenone 

Downstream Products

• 65-85-0 benzoic acid 
• 3445-76-9 5-phenyl-3H-1,2-dithiole-3-thione 
• 5653-30-5 2-[1,3]dithiolan-2-ylidene-1-phenyl-ethanone 
• 13196-40-2 N-phenyl-3-oxo-3-phenylpropanethioamide 
• 19607-10-4 2-(1,3-dithian-2-ylidene)-1-phenylethanone 
• 64-17-5 ethanol 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 74598-48-4 methyl 2-(benzoylmethylene)-4-imino-1,3-dithian-5-carboxylate 
• 74598-47-3 ethyl 2-(benzoylmethylene)-4-imino-1,3-dithian-5-carboxylate 
• 19017-95-9 3,5-di(benzoylmethylene)-1,2,4-trithiolane 
• 127458-44-0 (4R,5R)-2-(2-Oxo-2-phenyl-ethylidene)-[1,3]dithiolane-4,5-dicarboxylic acid dimethyl ester 
• 127458-44-0 (4S,5R)-2-[2-Oxo-2-phenyl-eth-(Z)-ylidene]-[1,3]dithiolane-4,5-dicarboxylic acid dimethyl ester 
• 6579-15-3 tetramethyl 2,3,4,5-thiophenetetracarboxylate 
• 1147550-11-5 ammonium thiocyanate 

Relevant academic research and scientific papers

Synthesis of densely substituted 1,3-butadienes through acid-catalyzed alkenylations of α-oxoketene dithioacetals with aldehydes

Aldehydes were proved to be viable reagents for implementing alkenylation of α-oxoketene dithioacetals. AlCl3 was found to be the best catalyst. The established reaction opened an avenue to access densely substituted 1,3-butadiene derivatives. The obtained product bears multiple reactive sites that can be converted into various valuable molecules. (Chemical Equation Presented).

ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES

The present invention relates to anilinopyrazole compounds of formula (1) in which R3 represents an aromatic 5- or 6-membered heteroaromatic ring which is optionally fused to phenyl, said heterocycle or fused heterocycle is optionally substituted, X represents a carboxylic acid, ester or amide, or sulfonamide, and the remaining groups are as defined in the text. It also relates to pharmaceutical compositions containing these materials and, and methods for treating diabetes and related disorders using these materials.

Synthesis of 5,6-Dihydro-4H-1,3,5-dithiazines, 2,3-Dihydro-6-thioxo-6H-1,3-thiazine, and 6-Amino-1,3-dithiins

Dithiolates (1) or (2), derived from compounds containing an active methylene or a sulphonamido-group, carbon disulphide and sodium or potassium hydroxide, underwent a Mannich reaction with formaldehyde and a primary amine to form 5,6-dihydro-1,3,5-dithiazines (3) or (4).The dithiolate (12), derived from ethyl acetoacetate, cyclised under the above conditions to ethyl 2,3-dihydro-3,4-dimethyl-6-thioxo-6H-1,3-thiazine-5-carboxylate (18).The dithiolates (20), derived from cyanoacetic ester, or (10), derived from acetophenone, interacted with formaldehyde and cyanoacetic esters or with 2-cyanoacrylates to form 6-amino-1,3-dithiins (26) or iminodithians (28).Methyl 6-amino-2--1,3-dithiin-5-carboxylate (26; R1=Et, R2=Me) formed N-acyl derivatives with aliphatic acid chlorides.On oxidation the dithiin (26; R1=Et, R2=Me) contracted to ethyl 2-cyano-2-(4-cyano-1,3-dithiolan-5-ylidene)acetate (31).