15190-17-7Relevant academic research and scientific papers
Alpha-cyanidation method of mono-alkyl substituted aniline
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Paragraph 0023; 0024; 0126; 0127; 0128; 0129, (2017/09/13)
The invention discloses an alpha-cyanidation method of mono-alkyl substituted aniline. According to the method, various aromatic, aliphatic, and heterocycle substituted secondary amines of anilines are taken as the raw materials, trimethylsilyl cyanide is
Role of (3-aminopropyl)tri alkoxysilanes in grafting of chlorosulphonic acid immobilized magnetic nanoparticles and their application as heterogeneous catalysts for the green synthesis of α-aminonitriles
Singh, Harminder,Rajput, Jaspreet Kaur,Arora, Priya,Jigyasa
, p. 84658 - 84671 (2016/10/31)
The surface modification of SiO2 coated Fe3O4 nanoparticles by grafting silane coupling agents is a highly significant approach to enhancing the interface interaction between the inorganic magnetic core and the organic fun
Efficient three-component Strecker reaction of acetals and aromatic amines catalysed by hafnium tetrachloride at room temperature
Zhang, Xue-Lin,Wu, Qin-Pei,Zhang, Qing-Shan
, p. 690 - 693 (2014/01/17)
A straightforward, mild, efficient, one-pot method has been found for the synthesis of á-aminonitriles via three-component Strecker reaction using acetals or cyclic acetals, curious aromatic amines and trimethylsilyl cyanide (TMSCN) catalysed by hafnium tetrachloride at room temperature. It is with good to excellent yields under mild conditions. This developed approach has been successfully applied for the synthesis of a wild rang of á-aminonitriles with a variety of functional groups.
One-pot three-component synthesis of α-aminonitriles using potassium hexacyanoferrate(II) as an eco-friendly cyanide source
Li, Zheng,Ma, Yuanhong,Xu, Jun,Shi, Jinghong,Cai, Hongfang
experimental part, p. 3922 - 3926 (2010/08/20)
An efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and potassium hexacyanoferrate(II) in the presence of benzoyl chloride as a promoter. This protocol has the features of use of eco-friendly cyanide source, high yield, and simple work-up procedure.
Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation
Shen, Zhi-Liang,Ji, Shun-Jun,Loh, Teck-Peng
, p. 8159 - 8163 (2008/12/21)
A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.
A Novel Synthesis of N-Substituted Amino Acids
Naim, S. Shawkat,Khan, Naseem H.,Siddiqui, Amin A.
, p. 622 - 624 (2007/10/02)
Addition of hydrocyanic acid to schiff bases has led to a method for the synthesis of N-substituted amino acid hydrochlorides in excellent yield (ca. 90percent).
