15190-69-9

Usage

Uses

Used in Organic Synthesis:
(4-methoxyphenyl)(phenylamino)acetonitrile is utilized as a key building block in organic synthesis for the preparation of a variety of chemical compounds. Its ability to undergo nucleophilic substitution and condensation reactions enables the formation of different functionalized molecules, contributing to the development of new chemical entities.
Used in Pharmaceutical Industry:
Due to its unique chemical structure and reactivity, (4-methoxyphenyl)(phenylamino)acetonitrile may have potential applications in the pharmaceutical industry. It could be used as a starting material or intermediate in the synthesis of pharmaceutical compounds, potentially leading to the discovery of new drugs with novel therapeutic properties.
Used in Agrochemical Industry:
Similarly, (4-methoxyphenyl)(phenylamino)acetonitrile may also find applications in the agrochemical industry. Its chemical properties could be harnessed in the development of new agrochemicals, such as pesticides or herbicides, that could offer improved efficacy and selectivity in agricultural settings.
Safety Precautions:
It is crucial to handle (4-methoxyphenyl)(phenylamino)acetonitrile with proper safety measures due to its potential hazards and toxicity. Adequate personal protective equipment, such as gloves and safety goggles, should be worn during its manipulation to minimize exposure risks. Additionally, it is important to follow proper disposal and storage procedures to ensure the safety of both individuals and the environment.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 62-53-3 aniline 
• 631-57-2 Acetyl cyanide 
• 2179-92-2 tri-n-butyltin cyanide 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 
• 151-50-8 potassium cyanide 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 143-33-9 sodium cyanide 
• 142-04-1 aniline hydrochloride 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 773837-37-9 sodium cyanide 

Downstream Products

• 154319-67-2 N-Phenyl-N-(α-cyano-p-methoxybenzyl)-p-fluorobenzamide 
• 1256842-42-8 ethyl 3-cyano-3-phenylamino-3-(4-methoxyphenyl)propanoate 
• 154319-87-6 N-Phenyl-N-(α-cyano-α-methyl-p-methoxybenzyl)-p-fluorobenzamide 
• 56301-84-9 1-(4-Methoxy-phenyl)-N¹-phenyl-ethane-1,2-diamine 
• 54615-68-8 (4-methoxy-phenyl)-phenylimino-acetonitrile 

Relevant academic research and scientific papers

Application of various types of alumina and nano-γ- Alumina sulfuric acid in the synthesis of α-aminonitriles derivatives: Comparative study

An efficient and green protocol for the synthesis of α-aminonitrile derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanide has been developed using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nano-γ

Three helical chain-based 3D coordination polymers: Solvent-induced syntheses, tunable structures and catalytic properties for the Strecker reaction

Three three-dimensional (3D) helical chain-based coordination polymers [Sc(aip)(OH)·(H2O)]n (1), [Sc2(aip)3]n (2) and [Sc2(nip)3]n (3) (H2aip = 5-aminoisoph

A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

Catalytic Strecker reaction: g-C3N4-anchored sulfonic acid organocatalyst for the synthesis of α-aminonitriles

Abstract: Efficient organocatalyst for enantioselective Strecker reaction was synthesized using g-C3N4 sheets (CN). CN-anchored sulfonic acid (CN-Bu-SO3H) was found to be a highly efficient and recoverable organocatalyst f

Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-t

Pd supported on methane diamine (propyl silane) functionalized Fe3O4 magnetic nanoparticles as an organic–inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES te

Radical Rearrangement of Aryl/Alkylidene Malononitriles via Aza Michael Addition/Decynoformylation/Addition Sequence: An Access to α-Aminonitriles and α-Aminoamides

An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of sub

Transition Metal Ions Regulated Structural and Catalytic Behaviors of Coordination Polymers

Three new coordination polymers (CPs), I [Cu(L)(H2O)]·2H2O, II [Zn(L)], and III [Ag(HL)(CH3CN)], were synthesized by employing a novel pyrazole-based dicarboxylate ligand (H2L) through a solvothermal strategy. Single-crystal structural analysis established that compounds I and II exhibit two-dimensional (2D) sheet structures, while compound III possesses a one-dimensional (1D) ladder structure due to the connectivity of terminal solvent moiety. The geometries of metal ions vary from square planar (Cu2+ ion) to distorted tetrahedral (Zn2+ and Ag+ ion). Topological study showed that compound I has made a (4·62)2(42·62·82) net, while compounds II and III have exposed common (44·62) SQL net and (42·6) net, respectively. The Lewis acidic nature of compounds I, II, and III has been confirmed with various heterogeneous catalytic reactions. For the first time, one-pot multicomponent synthesis of α-amino amidine has been performed by the three CPs and the reaction kinetics has been altered by the variation of Lewis acidic metal centers. The roles of metal ions for structural variations and the catalytic performances are investigated in a series of CPs.

KF/clinoptilolite nanoparticles as an efficient nanocatalyst for the Strecker synthesis of α-aminonitriles

Abstract: Potassium fluoride impregnated on clinoptilolite nanoparticles (KF/CP NPs) have been explored to serve as an effective and inexpensive heterogeneous catalyst for the one-pot three-component Strecker synthesis of a variety of α-aminonitriles at room temperature in ethanol as a green solvent. KF/CP NPs have been synthesized using simple impregnation techniques in aqueous media from readily available inexpensive starting materials and displayed its initial catalytic activity even after five runs. The easy preparation and separation of catalyst, simple procedure, mild reaction conditions, and excellent yields of products render this method as an attractive sustainable option. Graphic abstract: [Figure not available: see fulltext.]

Targeted development of hydrophilic porous polysulfonamide gels with catalytic activity

We report the use of a template and functional monomers in the synthesis of three novel polysulfonamide gels with new architectures and functional groups. These mesoporous polysulfonamide gels were prepared by the condensation polymerization of benzene-1,3-disulfonyl chloride (as the main precursor), linear monomers, and cross-linkers (as variable precursors) in the presence of a silica template by a combination of sol-gel chemistry and the nanocasting technique. In this synthesis pathway, in situ polymerization onto the template surface led to the construction of a silica/polymer nanocomposite. Next, after removal of the template, the nanocomposite gels were transformed into mesoporous polysulfonamide nanospheres. After the physicochemical identification of the synthesized materials, functionalized polysulfonamides were used as reusable novel catalysts with high efficiency for the Strecker reaction under mild conditions. These polymers have Br?nsted/Lewis acid active sites, a mesoporous structure, and hydrogen bonding. Moreover, since these polymers are hydrogels that can absorb water, they can promote the Strecker reaction through chemical absorption of the generated water as a driving force. Overall, this article describes a novel synthesis procedure and application of porous polysulfonamide gels.

Phosphine-Catalyzed Sequential Michael Addition between α-Aminonitriles and Methyl Acrylate for Cyclization: Synthesis of N-Aryl-Substituted Pyrrolidines

Abstract: N-Aryl-substituted pyrrolidine derivativeswere synthesized via tributylphosphine-catalyzed sequential Michael addition ofα-aminonitriles and methyl acrylate as starting materials. The first Michaeladdition between α-aminonitrile and methyl acryl