1521-41-1

Basic information

• Product Name: 3,4-DIMETHOXYBENZAMIDE
• Synonyms: 3,4-dimethoxy-benzamid;VERATRAMIDE;3,4-DIMETHOXYBENZAMIDE;BenzaMide, 3,4-diMethoxy-
• CAS NO: 1521-41-1
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• EINECS: 216-190-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 1521-41-1.mol
• Article Data: 45

Chemical Properties

• Melting Point: 163-164℃
• Boiling Point: 278.4 °C at 760 mmHg
• Flash Point: 126.1 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.00428mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,4-DIMETHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYBENZAMIDE(1521-41-1)
• EPA Substance Registry System: 3,4-DIMETHOXYBENZAMIDE(1521-41-1)

Safety Data

• Hazardous Substances Data: 1521-41-1(Hazardous Substances Data)

Usage

General Description

3,4-Dimethoxybenzamide is a chemical compound with the molecular formula C9H11NO3. It is a white solid that is used in various industrial and research applications. This chemical has several potential uses, including as a precursor in the production of pharmaceuticals and as an intermediate in the synthesis of other organic compounds. Additionally, 3,4-Dimethoxybenzamide may also have potential applications in the field of organic chemistry and materials science. It is important to handle this chemical with care, as it may present certain hazards and risks if not properly managed.

InChI:InChI=1/C9H11NO3/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5H,1-2H3,(H2,10,11)

Upstream product

• 77287-34-4 formamide 
• 93-07-2 Veratric acid 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 2169-98-4 3,4-Dimethoxy-benzaldehyde oxime 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 3943-77-9 ethyl veratrate 
• 15226-74-1 dicobalt octacarbonyl 
• 2859-78-1 4-Bromoveratrole 
• 5888-51-7 4-ethylveratrole 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 91-16-7 1,2-dimethoxybenzene 
• 75-52-5 nitromethane 
• 76195-90-9 N-isoquinolinio-3,4-dimethoxybenzamidate 

Downstream Products

• 67048-90-2 5-(3,4-dimethoxy-phenyl)-[1,3,4]oxathiazol-2-one 
• 2024-83-1 veratronitrile 
• 67-68-5 dimethyl sulfoxide 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 943518-63-6 N-(4-hydroxybenzyl)-3,4-dimethoxybenzamide 
• 122898-67-3 itopride 
• 86489-64-7 N-benzyl-3,4-dimethoxybenzamide 
• 1041381-45-6 2-(3,4-dimethoxyphenyl)-oxazolo[4,5:1,2][60]fullerene 
• 1444611-74-8 1-bromo-6,7-dimethoxy-3,4-diphenylisoquinoline 
• 1444611-72-6 1-chloro-6,7-dimethoxy-3,4-diphenylisoquinoline 
• 1404499-96-2 6,7-dimethoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 1220958-34-8 4-(1'-benzenesulfonylindol-3'-yl)-2-(3,4-dimethoxyphenyl)-oxazole 
• 5471-40-9 3,4,3',4'-tetramethoxy-bibenzyl-α-ylamine 
• 67113-95-5 3-(3,4-dimethoxy-phenyl)-isothiazole-4,5-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Ruthenium-catalyzed cyclization of aromatic nitriles with alkenes: Stereoselective synthesis of (Z)-3-methyleneisoindolin-1-ones

Aromatic nitriles underwent cyclization with activated alkenes in the presence of a ruthenium catalyst, AgSbF6, and Cu(OAc)2·H2O providing substituted 3-methyleneisoindolin-1-ones with high Z-stereoselectivity. The Z-stereoselectivity of the 3-methyleneisoindolin-1-one moiety was controlled by the intramolecular hydrogen bonding.

Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides

A LiOH-promoted hydrolysis selective C-N cleavage of twisted N-acyl glutarimide for the synthesis of primary amides under mild conditions has been developed. The reaction is triggered by a ring opening of glutarimide followed by C-N cleavage to afford primary amides using 2 equiv of LiOH as the base at room temperature. The efficacy of the reactions was considered and administrated for various aryl and alkyl substituents in good yield with high selectivity. Moreover, gram-scale synthesis of primary amides using a continuous flow method was achieved. It is noted that our new methodology can apply under both batch and flow conditions for synthetic and industrial applications.

Transamidation for the Synthesis of Primary Amides at Room Temperature

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25 °C, the desired primary amide product is formed in good yield with good funcctional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.